Development of Soft Tissue Sarcomas in Ribosomal Proteins L5 and S24 Heterozygous Mice

Diamond-Blackfan anemia (DBA) is an inherited bone marrow failure syndrome associated with ribosomal protein (RP) gene mutations. Recent studies have also demonstrated an increased risk of cancer predisposition among DBA patients. In this study, we report the formation of soft tissue sarcoma in the...

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Autores principales: Kazerounian, Shideh, Ciarlini, Pedro D.S.C., Yuan, Daniel, Ghazvinian, Roxanne, Alberich-Jorda, Meritxell, Joshi, Mugdha, Zhang, Hong, Beggs, Alan H., Gazda, Hanna T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2016
Materias:
Short Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679378/
https://www.ncbi.nlm.nih.gov/pubmed/26722357
http://dx.doi.org/10.7150/jca.13292
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author Kazerounian, Shideh
Ciarlini, Pedro D.S.C.
Yuan, Daniel
Ghazvinian, Roxanne
Alberich-Jorda, Meritxell
Joshi, Mugdha
Zhang, Hong
Beggs, Alan H.
Gazda, Hanna T.
author_facet Kazerounian, Shideh
Ciarlini, Pedro D.S.C.
Yuan, Daniel
Ghazvinian, Roxanne
Alberich-Jorda, Meritxell
Joshi, Mugdha
Zhang, Hong
Beggs, Alan H.
Gazda, Hanna T.
author_sort Kazerounian, Shideh
collection PubMed
description Diamond-Blackfan anemia (DBA) is an inherited bone marrow failure syndrome associated with ribosomal protein (RP) gene mutations. Recent studies have also demonstrated an increased risk of cancer predisposition among DBA patients. In this study, we report the formation of soft tissue sarcoma in the Rpl5 and Rps24 heterozygous mice. Our observation suggests that even though one wild-type allele of the Rpl5 or Rps24 gene prevents anemia in these mice, it still predisposes them to cancer development.
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spelling pubmed-46793782016-01-01 Development of Soft Tissue Sarcomas in Ribosomal Proteins L5 and S24 Heterozygous Mice Kazerounian, Shideh Ciarlini, Pedro D.S.C. Yuan, Daniel Ghazvinian, Roxanne Alberich-Jorda, Meritxell Joshi, Mugdha Zhang, Hong Beggs, Alan H. Gazda, Hanna T. J Cancer Short Research Communication Diamond-Blackfan anemia (DBA) is an inherited bone marrow failure syndrome associated with ribosomal protein (RP) gene mutations. Recent studies have also demonstrated an increased risk of cancer predisposition among DBA patients. In this study, we report the formation of soft tissue sarcoma in the Rpl5 and Rps24 heterozygous mice. Our observation suggests that even though one wild-type allele of the Rpl5 or Rps24 gene prevents anemia in these mice, it still predisposes them to cancer development. Ivyspring International Publisher 2016-01-01 /pmc/articles/PMC4679378/ /pubmed/26722357 http://dx.doi.org/10.7150/jca.13292 Text en © Ivyspring International Publisher. Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. See http://ivyspring.com/terms for terms and conditions.
spellingShingle Short Research Communication
Kazerounian, Shideh
Ciarlini, Pedro D.S.C.
Yuan, Daniel
Ghazvinian, Roxanne
Alberich-Jorda, Meritxell
Joshi, Mugdha
Zhang, Hong
Beggs, Alan H.
Gazda, Hanna T.
Development of Soft Tissue Sarcomas in Ribosomal Proteins L5 and S24 Heterozygous Mice
title Development of Soft Tissue Sarcomas in Ribosomal Proteins L5 and S24 Heterozygous Mice
title_full Development of Soft Tissue Sarcomas in Ribosomal Proteins L5 and S24 Heterozygous Mice
title_fullStr Development of Soft Tissue Sarcomas in Ribosomal Proteins L5 and S24 Heterozygous Mice
title_full_unstemmed Development of Soft Tissue Sarcomas in Ribosomal Proteins L5 and S24 Heterozygous Mice
title_short Development of Soft Tissue Sarcomas in Ribosomal Proteins L5 and S24 Heterozygous Mice
title_sort development of soft tissue sarcomas in ribosomal proteins l5 and s24 heterozygous mice
topic Short Research Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679378/
https://www.ncbi.nlm.nih.gov/pubmed/26722357
http://dx.doi.org/10.7150/jca.13292
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