ZHX1 Inhibits Gastric Cancer Cell Growth through Inducing Cell-Cycle Arrest and Apoptosis

Zinc-fingers and homeoboxes 1 (ZHX1) was implicated in the carcinogenesis of human cancers. However, little is known about the role of ZHX1 in gastric cancer (GC). Here, we found that ZHX1 was downregulated in GC tissues compared with paired non-tumor tissues and loss of ZHX1 expression correlated w...

Descripción completa

Detalles Bibliográficos
Autores principales: Ma, Xingjie, Huang, Minlu, Wang, Zhenqiang, Liu, Bingya, Zhu, Zhenggang, Li, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679382/
https://www.ncbi.nlm.nih.gov/pubmed/26722361
http://dx.doi.org/10.7150/jca.12973
_version_ 1782405571674112000
author Ma, Xingjie
Huang, Minlu
Wang, Zhenqiang
Liu, Bingya
Zhu, Zhenggang
Li, Chen
author_facet Ma, Xingjie
Huang, Minlu
Wang, Zhenqiang
Liu, Bingya
Zhu, Zhenggang
Li, Chen
author_sort Ma, Xingjie
collection PubMed
description Zinc-fingers and homeoboxes 1 (ZHX1) was implicated in the carcinogenesis of human cancers. However, little is known about the role of ZHX1 in gastric cancer (GC). Here, we found that ZHX1 was downregulated in GC tissues compared with paired non-tumor tissues and loss of ZHX1 expression correlated with aggressive clinical characteristics of GC patients. ZHX1 induced G1/S arrest by decreasing cyclin D1 and cyclin E expression, and induced cell apoptosis by Bcl2 downregulation and Bax and cleaved Caspase-3 upregulation. Our findings revealed that ZHX1 could inhibit cell growth through inducing cell-cycle arrest and apoptosis in GC.
format Online
Article
Text
id pubmed-4679382
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Ivyspring International Publisher
record_format MEDLINE/PubMed
spelling pubmed-46793822016-01-01 ZHX1 Inhibits Gastric Cancer Cell Growth through Inducing Cell-Cycle Arrest and Apoptosis Ma, Xingjie Huang, Minlu Wang, Zhenqiang Liu, Bingya Zhu, Zhenggang Li, Chen J Cancer Research Paper Zinc-fingers and homeoboxes 1 (ZHX1) was implicated in the carcinogenesis of human cancers. However, little is known about the role of ZHX1 in gastric cancer (GC). Here, we found that ZHX1 was downregulated in GC tissues compared with paired non-tumor tissues and loss of ZHX1 expression correlated with aggressive clinical characteristics of GC patients. ZHX1 induced G1/S arrest by decreasing cyclin D1 and cyclin E expression, and induced cell apoptosis by Bcl2 downregulation and Bax and cleaved Caspase-3 upregulation. Our findings revealed that ZHX1 could inhibit cell growth through inducing cell-cycle arrest and apoptosis in GC. Ivyspring International Publisher 2016-01-01 /pmc/articles/PMC4679382/ /pubmed/26722361 http://dx.doi.org/10.7150/jca.12973 Text en © Ivyspring International Publisher. Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. See http://ivyspring.com/terms for terms and conditions.
spellingShingle Research Paper
Ma, Xingjie
Huang, Minlu
Wang, Zhenqiang
Liu, Bingya
Zhu, Zhenggang
Li, Chen
ZHX1 Inhibits Gastric Cancer Cell Growth through Inducing Cell-Cycle Arrest and Apoptosis
title ZHX1 Inhibits Gastric Cancer Cell Growth through Inducing Cell-Cycle Arrest and Apoptosis
title_full ZHX1 Inhibits Gastric Cancer Cell Growth through Inducing Cell-Cycle Arrest and Apoptosis
title_fullStr ZHX1 Inhibits Gastric Cancer Cell Growth through Inducing Cell-Cycle Arrest and Apoptosis
title_full_unstemmed ZHX1 Inhibits Gastric Cancer Cell Growth through Inducing Cell-Cycle Arrest and Apoptosis
title_short ZHX1 Inhibits Gastric Cancer Cell Growth through Inducing Cell-Cycle Arrest and Apoptosis
title_sort zhx1 inhibits gastric cancer cell growth through inducing cell-cycle arrest and apoptosis
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679382/
https://www.ncbi.nlm.nih.gov/pubmed/26722361
http://dx.doi.org/10.7150/jca.12973
work_keys_str_mv AT maxingjie zhx1inhibitsgastriccancercellgrowththroughinducingcellcyclearrestandapoptosis
AT huangminlu zhx1inhibitsgastriccancercellgrowththroughinducingcellcyclearrestandapoptosis
AT wangzhenqiang zhx1inhibitsgastriccancercellgrowththroughinducingcellcyclearrestandapoptosis
AT liubingya zhx1inhibitsgastriccancercellgrowththroughinducingcellcyclearrestandapoptosis
AT zhuzhenggang zhx1inhibitsgastriccancercellgrowththroughinducingcellcyclearrestandapoptosis
AT lichen zhx1inhibitsgastriccancercellgrowththroughinducingcellcyclearrestandapoptosis

Ejemplares similares