Excess Nitric Oxide Activates TRPV1-Ca(2+)-Calpain Signaling and Promotes PEST-dependent Degradation of Liver X Receptor α

Excess nitric oxide (NO) deregulates cholesterol metabolism in macrophage foam cells, yet the underlying molecular mechanism is incompletely understood. To investigate the mechanism, we found that in macrophages, treatment with NO donors S-nitroso-N-acetyl-D,L-penicillamine (SNAP) or diethylenetriam...

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Detalles Bibliográficos
Autores principales: Zhao, Jin-Feng, Shyue, Song-Kun, Lee, Tzong-Shyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679395/
https://www.ncbi.nlm.nih.gov/pubmed/26722214
http://dx.doi.org/10.7150/ijbs.13549

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679395/
https://www.ncbi.nlm.nih.gov/pubmed/26722214
http://dx.doi.org/10.7150/ijbs.13549

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