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Body mass index and risk of knee osteoarthritis: systematic review and meta-analysis of prospective studies
OBJECTIVES: Obesity is suggested to be a risk factor for knee osteoarthritis (OA). This meta-analysis aimed to examine the relationship between body mass index (BMI) and the risk of knee OA in published prospective studies. DESIGN: Meta-analysis. STUDIES REVIEWED: An extensive literature review was...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679914/ https://www.ncbi.nlm.nih.gov/pubmed/26656979 http://dx.doi.org/10.1136/bmjopen-2014-007568 |
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author | Zheng, Huaqing Chen, Changhong |
author_facet | Zheng, Huaqing Chen, Changhong |
author_sort | Zheng, Huaqing |
collection | PubMed |
description | OBJECTIVES: Obesity is suggested to be a risk factor for knee osteoarthritis (OA). This meta-analysis aimed to examine the relationship between body mass index (BMI) and the risk of knee OA in published prospective studies. DESIGN: Meta-analysis. STUDIES REVIEWED: An extensive literature review was performed, and relevant studies published in English were retrieved from the computerised databases MEDLINE, EMBASE and Cochrane. METHODS: The effect estimate (RR or HR) and its 95% CI are investigated on the basis of the evaluation of differences of knee OR risk in overweight or obesity versus those with normal weight. Category-specific risk estimates were further transformed into estimates of the RR in terms of per increase of 5 in BMI by using the generalised least-squares method for trend estimation. Studies were independently reviewed by two investigators. Subgroup analysis was performed. Heterogeneity and publication bias were assessed. Data from eligible studies were extracted, and the meta-analysis was performed by using the STATA software V.12.0. RESULTS: 14 studies were finally included in the analysis. The results showed that overweight and obesity were significantly associated with higher knee OA risks of 2.45 (95% CI 1.88 to 3.20, p<0.001) and 4.55 (95% CI 2.90 to 7.13, p<0.001), respectively. The risk of knee OA increases by 35% (95% CI 1.18 to 1.53, p<0.001) with a 5 kg/m(2) increase in BMI. Subgroup analysis showed that obesity was an independent predictor of knee OA risk regardless of the study country, sample size, gender proportion of participants, duration of follow-up, presence of adjusted knee injury and assessed study quality above or below an NOS score of 8. No publication bias was detected. CONCLUSIONS: Obesity was a robust risk factor for knee OA. Professionals should take a possible weight reduction into account for the treatment of knee OA whenever a patient is significantly overweight. |
format | Online Article Text |
id | pubmed-4679914 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-46799142015-12-22 Body mass index and risk of knee osteoarthritis: systematic review and meta-analysis of prospective studies Zheng, Huaqing Chen, Changhong BMJ Open Health Services Research OBJECTIVES: Obesity is suggested to be a risk factor for knee osteoarthritis (OA). This meta-analysis aimed to examine the relationship between body mass index (BMI) and the risk of knee OA in published prospective studies. DESIGN: Meta-analysis. STUDIES REVIEWED: An extensive literature review was performed, and relevant studies published in English were retrieved from the computerised databases MEDLINE, EMBASE and Cochrane. METHODS: The effect estimate (RR or HR) and its 95% CI are investigated on the basis of the evaluation of differences of knee OR risk in overweight or obesity versus those with normal weight. Category-specific risk estimates were further transformed into estimates of the RR in terms of per increase of 5 in BMI by using the generalised least-squares method for trend estimation. Studies were independently reviewed by two investigators. Subgroup analysis was performed. Heterogeneity and publication bias were assessed. Data from eligible studies were extracted, and the meta-analysis was performed by using the STATA software V.12.0. RESULTS: 14 studies were finally included in the analysis. The results showed that overweight and obesity were significantly associated with higher knee OA risks of 2.45 (95% CI 1.88 to 3.20, p<0.001) and 4.55 (95% CI 2.90 to 7.13, p<0.001), respectively. The risk of knee OA increases by 35% (95% CI 1.18 to 1.53, p<0.001) with a 5 kg/m(2) increase in BMI. Subgroup analysis showed that obesity was an independent predictor of knee OA risk regardless of the study country, sample size, gender proportion of participants, duration of follow-up, presence of adjusted knee injury and assessed study quality above or below an NOS score of 8. No publication bias was detected. CONCLUSIONS: Obesity was a robust risk factor for knee OA. Professionals should take a possible weight reduction into account for the treatment of knee OA whenever a patient is significantly overweight. BMJ Publishing Group 2015-12-11 /pmc/articles/PMC4679914/ /pubmed/26656979 http://dx.doi.org/10.1136/bmjopen-2014-007568 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Health Services Research Zheng, Huaqing Chen, Changhong Body mass index and risk of knee osteoarthritis: systematic review and meta-analysis of prospective studies |
title | Body mass index and risk of knee osteoarthritis: systematic review and meta-analysis of prospective studies |
title_full | Body mass index and risk of knee osteoarthritis: systematic review and meta-analysis of prospective studies |
title_fullStr | Body mass index and risk of knee osteoarthritis: systematic review and meta-analysis of prospective studies |
title_full_unstemmed | Body mass index and risk of knee osteoarthritis: systematic review and meta-analysis of prospective studies |
title_short | Body mass index and risk of knee osteoarthritis: systematic review and meta-analysis of prospective studies |
title_sort | body mass index and risk of knee osteoarthritis: systematic review and meta-analysis of prospective studies |
topic | Health Services Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679914/ https://www.ncbi.nlm.nih.gov/pubmed/26656979 http://dx.doi.org/10.1136/bmjopen-2014-007568 |
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