Cargando…

Regulatory Effect of Iguratimod on the Balance of Th Subsets and Inhibition of Inflammatory Cytokines in Patients with Rheumatoid Arthritis

Objective. To expand upon the role of iguratimod (T-614) in the treatment of rheumatoid arthritis (RA), we investigated whether the Th1, Th17, follicular helper T cells (Tfh), and regulatory T cells (Treg) imbalance could be reversed by iguratimod and the clinical implications of this reversal. Meth...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Yunzhi, Zhu, Qi, Song, Jinglve, Liu, Hongli, Miao, Yutong, Yang, Fan, Wang, Feiyan, Cheng, Wenjing, Xi, Yebin, Niu, Xiaoyin, He, Dongyi, Chen, Guangjie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4680115/ https://www.ncbi.nlm.nih.gov/pubmed/26713003 http://dx.doi.org/10.1155/2015/356040

Ejemplares similares

T-614 Promotes Osteoblastic Cell Differentiation by Increasing Dlx5 Expression and Regulating the Activation of p38 and NF-κB
por: Song, Jinglue, et al.
Publicado: (2018)

Clinical Biomarkers and Pathogenic-Related Cytokines in Rheumatoid Arthritis
por: Niu, Xiaoyin, et al.
Publicado: (2014)

Efficacy and Safety of Iguratimod for the Treatment of Rheumatoid Arthritis
por: Li, Jiangtao, et al.
Publicado: (2013)

Iguratimod as a New Drug for Rheumatoid Arthritis: Current Landscape
por: Xie, Sisi, et al.
Publicado: (2020)

Corrigendum: Iguratimod as a New Drug for Rheumatoid Arthritis: Current Landscape
por: Xie, Sisi, et al.
Publicado: (2020)

Iguratimod Inhibits the Aggressiveness of Rheumatoid Fibroblast-Like Synoviocytes
por: Lin, Jin, et al.
Publicado: (2019)

Influence of Iguratimod on Bone Metabolism in Patients with Rheumatoid Arthritis: A Meta-analysis
por: Deng, Li, et al.
Publicado: (2022)

Conflict between efficacy and economy in rheumatoid arthritis treatment: Iguratimod is found at a compromise
por: Tanaka, Masao
Publicado: (2021)

The Effectiveness and Retention Rate of Iguratimod in Japanese Rheumatoid Arthritis Patients with/without Methotrexate in Daily Medical Care
por: Inoue, Asuka, et al.
Publicado: (2020)

Iguratimod: Novel Molecular Insights and a New csDMARD for Rheumatoid Arthritis, from Japan to the World
por: Nozaki, Yuji
Publicado: (2021)

Preparation of a Major Metabolite of Iguratimod and Simultaneous Assay of Iguratimod and Its Metabolite by HPLC in Rat Plasma
por: Han, Jun-ping, et al.
Publicado: (2019)

T Cell Vaccination Inhibits Th1/Th17/Tfh Frequencies and Production of Autoantibodies in Collagen-Induced Arthritis
por: Li, Shan, et al.
Publicado: (2013)

Iguratimod efficacy in palindromic rheumatism treatment
por: Yuan, Fangfang, et al.
Publicado: (2023)

Iguratimod promotes transformation of mononuclear macrophages in elderly patients with rheumatoid arthritis by nuclear factor-κB pathway
por: Liu, Sha, et al.
Publicado: (2021)

Clinical Efficacy of Methotrexate Combined with Iguratimod on Patients with Rheumatoid Arthritis and Its Influence on the Expression Levels of HOTAIR in Serum
por: Tan, Jingya, et al.
Publicado: (2021)

Effectiveness of iguratimod as monotherapy or combined therapy in patients with rheumatoid arthritis: a systematic review and meta-analysis of RCTs
por: Hu, Chao-Jun, et al.
Publicado: (2021)

Effectiveness and Safety of Iguratimod Monotherapy or Combined With Methotrexate in Treating Rheumatoid Arthritis: A Systematic Review and Meta-Analysis
por: Ouyang, Dan, et al.
Publicado: (2022)

A prospective observational cohort study of the efficacy of tofacitinib plus iguratimod on rheumatoid arthritis with usual interstitial pneumonia
por: Wang, Shuhua, et al.
Publicado: (2023)

The Role of Different Subsets of Regulatory T Cells in Immunopathogenesis of Rheumatoid Arthritis
por: Gol-Ara, Maryam, et al.
Publicado: (2012)

Serum matrix metalloproteinase 3 levels are associated with an effect of iguratimod as add-on therapy to biological DMARDs in patients with rheumatoid arthritis
por: Tokai, Nao, et al.
Publicado: (2018)

Effectiveness and safety of iguratimod treatment in patients with active rheumatoid arthritis in Chinese: A nationwide, prospective real-world study
por: Mu, Rong, et al.
Publicado: (2021)

Correction: Serum matrix metalloproteinase 3 levels are associated with an effect of iguratimod as add-on therapy to biological DMARDs in patients with rheumatoid arthritis
por: Tokai, Nao, et al.
Publicado: (2019)

Prolonged presence of SARS-CoV-2 in a COVID-19 case with rheumatoid arthritis taking iguratimod treated with ciclesonide()
por: Baba, Hiroaki, et al.
Publicado: (2020)

Iguratimod alleviates tubulo-interstitial injury in mice with lupus
por: Xue, Leixi, et al.
Publicado: (2022)

The Effect and Safety of Iguratimod Combined With Methotrexate on Rheumatoid Arthritis: A Systematic Review and Meta-Analysis Based on a Randomized Controlled Trial
por: Zeng, Liuting, et al.
Publicado: (2022)

Novel Senescent Regulatory T-Cell Subset with Impaired Suppressive Function in Rheumatoid Arthritis
por: Fessler, Johannes, et al.
Publicado: (2017)

Efficacy and safety of iguratimod combined with methotrexate vs. methotrexate alone in rheumatoid arthritis: A systematic review and meta-analysis of randomized controlled trials
por: Chen, L.-J., et al.
Publicado: (2020)

CD169+ Monocyte and Regulatory T Cell Subsets Are Associated with Disease Activity in Rheumatoid Arthritis
por: Eakin, Amanda J., et al.
Publicado: (2022)

Rheumatoid synovial fibroblasts differentiate into distinct subsets in the presence of cytokines and cartilage
por: Croft, Adam P., et al.
Publicado: (2016)

Iguratimod Restrains Circulating Follicular Helper T Cell Function by Inhibiting Glucose Metabolism via Hif1α-HK2 Axis in Rheumatoid Arthritis
por: Bai, Ziran, et al.
Publicado: (2022)

Sinomenine Inhibits the Progression of Rheumatoid Arthritis by Regulating the Secretion of Inflammatory Cytokines and Monocyte/Macrophage Subsets
por: Liu, Weiwei, et al.
Publicado: (2018)

Allergic Skin Rash Caused by Iguratimod: A Report of Two Cases
por: Lu, Wentian, et al.
Publicado: (2022)

Dendritic cell subsets in rheumatoid arthritis
por: Summers, K, et al.
Publicado: (2001)

Ciclesonide/iguratimod: Prolonged presence of SARS-CoV-2: case report
Publicado: (2020)

Randomised, Double-Blind, Placebo-Controlled Study of Iguratimod in the Treatment of Active Spondyloarthritis
por: Li, Yan, et al.
Publicado: (2021)

Iguratimod as an alternative therapy for systemic sclerosis and prevention of the occurrence of ischemic digital ulcer
por: Yan, Qingran, et al.
Publicado: (2023)

Abnormalities of Peripheral Lymphocyte Subsets in Rheumatoid Arthritis Patients Complicated with Osteoporosis
por: Cheng, Ting, et al.
Publicado: (2022)

Prevention of Immune Nephritis by the Small Molecular Weight Immunomodulator Iguratimod in MRL/lpr Mice
por: Yan, Qingran, et al.
Publicado: (2014)

Iguratimod as an alternative induction therapy for refractory lupus nephritis: a preliminary investigational study
por: Kang, Yuening, et al.
Publicado: (2020)

Research progress on the clinical application and mechanism of iguratimod in the treatment of autoimmune diseases and rheumatic diseases
por: Long, Zhiyong, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_8bs2dr5k7vgakcle9hfrrpbei4