Getting controls under control: the time is now for immunohistochemistry

For several decades, immunohistochemistry (IHC), more specifically diagnostic IHC (dIHC), has been considered an art rather than a laboratory test. There was no clarity about what test performance characteristics are relevant to dIHC, test performance characteristics were not fully defined for dIHC...

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Detalles Bibliográficos
Autores principales: Torlakovic, Emina Emilia, Nielsen, Søren, Vyberg, Mogens, Taylor, Clive R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4680144/
https://www.ncbi.nlm.nih.gov/pubmed/26286753
http://dx.doi.org/10.1136/jclinpath-2014-202705
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author Torlakovic, Emina Emilia
Nielsen, Søren
Vyberg, Mogens
Taylor, Clive R
author_facet Torlakovic, Emina Emilia
Nielsen, Søren
Vyberg, Mogens
Taylor, Clive R
author_sort Torlakovic, Emina Emilia
collection PubMed
description For several decades, immunohistochemistry (IHC), more specifically diagnostic IHC (dIHC), has been considered an art rather than a laboratory test. There was no clarity about what test performance characteristics are relevant to dIHC, test performance characteristics were not fully defined for dIHC and partly as a consequence of that, there were no standardised controls or reference standards. Herein, we discuss the role of standardisation of external controls for test performance characteristics and the role of standardised controls and reference standards for overall standardisation of IHC.
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spelling pubmed-46801442015-12-18 Getting controls under control: the time is now for immunohistochemistry Torlakovic, Emina Emilia Nielsen, Søren Vyberg, Mogens Taylor, Clive R J Clin Pathol Review For several decades, immunohistochemistry (IHC), more specifically diagnostic IHC (dIHC), has been considered an art rather than a laboratory test. There was no clarity about what test performance characteristics are relevant to dIHC, test performance characteristics were not fully defined for dIHC and partly as a consequence of that, there were no standardised controls or reference standards. Herein, we discuss the role of standardisation of external controls for test performance characteristics and the role of standardised controls and reference standards for overall standardisation of IHC. BMJ Publishing Group 2015-11 2015-08-18 /pmc/articles/PMC4680144/ /pubmed/26286753 http://dx.doi.org/10.1136/jclinpath-2014-202705 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Review
Torlakovic, Emina Emilia
Nielsen, Søren
Vyberg, Mogens
Taylor, Clive R
Getting controls under control: the time is now for immunohistochemistry
title Getting controls under control: the time is now for immunohistochemistry
title_full Getting controls under control: the time is now for immunohistochemistry
title_fullStr Getting controls under control: the time is now for immunohistochemistry
title_full_unstemmed Getting controls under control: the time is now for immunohistochemistry
title_short Getting controls under control: the time is now for immunohistochemistry
title_sort getting controls under control: the time is now for immunohistochemistry
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4680144/
https://www.ncbi.nlm.nih.gov/pubmed/26286753
http://dx.doi.org/10.1136/jclinpath-2014-202705
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