There is no ‘Conundrum’ of InsP(6)

Indirect assays have claimed to quantify phytate (InsP(6)) levels in human biofluids, but these have been based on the initial assumption that InsP(6) is there, an assumption that our more direct assays disprove. We have shown that InsP(6) does not and cannot (because of the presence of an active In...

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Detalles Bibliográficos
Autores principales: Irvine, Robin F., Bulley, Simon J., Wilson, Miranda S., Saiardi, Adolfo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2015
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4680572/
https://www.ncbi.nlm.nih.gov/pubmed/26581573
http://dx.doi.org/10.1098/rsob.150181
Descripción
Sumario:Indirect assays have claimed to quantify phytate (InsP(6)) levels in human biofluids, but these have been based on the initial assumption that InsP(6) is there, an assumption that our more direct assays disprove. We have shown that InsP(6) does not and cannot (because of the presence of an active InsP(6) phosphatase in serum) exist in mammalian serum or urine. Therefore, any physiological effects of dietary InsP(6) can only be due either to its actions in the gut as a polyvalent cation chelator, or to inositol generated by its dephosphorylation by gut microflora.

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