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Outcome of patients with autoimmune diseases in the intensive care unit: a mixed cluster analysis
OBJECTIVES: The interest on autoimmune diseases (ADs) and their outcome at the intensive care unit (ICU) has increased due to the clinical challenge for diagnosis and management as well as for prognosis. The current work presents a-year experience on these topics in a tertiary hospital. METHODS: The...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BMJ Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4680590/ https://www.ncbi.nlm.nih.gov/pubmed/26688741 http://dx.doi.org/10.1136/lupus-2015-000122 |
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author | Bernal-Macías, Santiago Reyes-Beltrán, Benjamín Molano-González, Nicolás Augusto Vega, Daniel Bichernall, Claudia Díaz, Luis Aurelio Rojas-Villarraga, Adriana Anaya, Juan-Manuel |
author_facet | Bernal-Macías, Santiago Reyes-Beltrán, Benjamín Molano-González, Nicolás Augusto Vega, Daniel Bichernall, Claudia Díaz, Luis Aurelio Rojas-Villarraga, Adriana Anaya, Juan-Manuel |
author_sort | Bernal-Macías, Santiago |
collection | PubMed |
description | OBJECTIVES: The interest on autoimmune diseases (ADs) and their outcome at the intensive care unit (ICU) has increased due to the clinical challenge for diagnosis and management as well as for prognosis. The current work presents a-year experience on these topics in a tertiary hospital. METHODS: The mixed-cluster methodology based on multivariate descriptive methods such as principal component analysis and multiple correspondence analyses was performed to summarize sets of related variables with strong associations and common clinical context. RESULTS: Fifty adult patients with ADs with a mean age of 46.7±17.55 years were assessed. The two most common diagnoses were systemic lupus erythematosus and systemic sclerosis, registered in 45% and 20% of patients, respectively. The main causes of admission to ICU were infection and AD flare up, observed in 36% and 24%, respectively. Mortality during ICU stay was 24%. The length of hospital stay before ICU admission, shock, vasopressors, mechanical ventilation, abdominal sepsis, Glasgow score and plasmapheresis were all factors associated with mortality. Two new clinical clusters variables (NCVs) were defined: Time ICU and ICU Support Profile, which were associated with survivor and no survivor variables. CONCLUSIONS: Identification of single factors and groups of factors from NCVs will allow implementation of early and aggressive therapies in patients with ADs at the ICU in order to avoid fatal outcomes |
format | Online Article Text |
id | pubmed-4680590 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-46805902015-12-18 Outcome of patients with autoimmune diseases in the intensive care unit: a mixed cluster analysis Bernal-Macías, Santiago Reyes-Beltrán, Benjamín Molano-González, Nicolás Augusto Vega, Daniel Bichernall, Claudia Díaz, Luis Aurelio Rojas-Villarraga, Adriana Anaya, Juan-Manuel Lupus Sci Med Epidemiology and Outcomes OBJECTIVES: The interest on autoimmune diseases (ADs) and their outcome at the intensive care unit (ICU) has increased due to the clinical challenge for diagnosis and management as well as for prognosis. The current work presents a-year experience on these topics in a tertiary hospital. METHODS: The mixed-cluster methodology based on multivariate descriptive methods such as principal component analysis and multiple correspondence analyses was performed to summarize sets of related variables with strong associations and common clinical context. RESULTS: Fifty adult patients with ADs with a mean age of 46.7±17.55 years were assessed. The two most common diagnoses were systemic lupus erythematosus and systemic sclerosis, registered in 45% and 20% of patients, respectively. The main causes of admission to ICU were infection and AD flare up, observed in 36% and 24%, respectively. Mortality during ICU stay was 24%. The length of hospital stay before ICU admission, shock, vasopressors, mechanical ventilation, abdominal sepsis, Glasgow score and plasmapheresis were all factors associated with mortality. Two new clinical clusters variables (NCVs) were defined: Time ICU and ICU Support Profile, which were associated with survivor and no survivor variables. CONCLUSIONS: Identification of single factors and groups of factors from NCVs will allow implementation of early and aggressive therapies in patients with ADs at the ICU in order to avoid fatal outcomes BMJ Publishing Group 2015-12-01 /pmc/articles/PMC4680590/ /pubmed/26688741 http://dx.doi.org/10.1136/lupus-2015-000122 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Epidemiology and Outcomes Bernal-Macías, Santiago Reyes-Beltrán, Benjamín Molano-González, Nicolás Augusto Vega, Daniel Bichernall, Claudia Díaz, Luis Aurelio Rojas-Villarraga, Adriana Anaya, Juan-Manuel Outcome of patients with autoimmune diseases in the intensive care unit: a mixed cluster analysis |
title | Outcome of patients with autoimmune diseases in the intensive care unit: a mixed cluster analysis |
title_full | Outcome of patients with autoimmune diseases in the intensive care unit: a mixed cluster analysis |
title_fullStr | Outcome of patients with autoimmune diseases in the intensive care unit: a mixed cluster analysis |
title_full_unstemmed | Outcome of patients with autoimmune diseases in the intensive care unit: a mixed cluster analysis |
title_short | Outcome of patients with autoimmune diseases in the intensive care unit: a mixed cluster analysis |
title_sort | outcome of patients with autoimmune diseases in the intensive care unit: a mixed cluster analysis |
topic | Epidemiology and Outcomes |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4680590/ https://www.ncbi.nlm.nih.gov/pubmed/26688741 http://dx.doi.org/10.1136/lupus-2015-000122 |
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