Antibody induced CD4 down-modulation of T cells is site-specifically mediated by CD64(+) cells

Treatment of PBMC with the CD4-specific mAb BT-061 induces CD4 down-modulation of T cells. Here we report that addition of BT-061 to purified T cells did not confer this effect, whereas incubation of T cells in BT-061 coated wells restored CD4 down-modulation. These results implied that Fcγ receptor...

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Detalles Bibliográficos
Autores principales: Vogel, Stephanie, Grabski, Elena, Buschjäger, Daniela, Klawonn, Frank, Döring, Marius, Wang, Junxi, Fletcher, Erika, Bechmann, Ingo, Witte, Torsten, Durisin, Martin, Schraven, Burkhart, Mangsbo, Sara M., Schönfeld, Kurt, Czeloth, Niklas, Kalinke, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4680940/
https://www.ncbi.nlm.nih.gov/pubmed/26670584
http://dx.doi.org/10.1038/srep18308

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