Enhanced therapeutic effect using sequential administration of antigenically distinct oncolytic viruses expressing oncostatin M in a Syrian hamster orthotopic pancreatic cancer model

BACKGROUND: The limited efficacy of current treatments against pancreatic cancer has prompted the search of new alternatives such as virotherapy. Activation of the immune response against cancer cells is emerging as one of the main mechanisms of action of oncolytic viruses (OV). Direct oncolysis rel...

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Detalles Bibliográficos
Autores principales: Nistal-Villan, Estanislao, Bunuales, Maria, Poutou, Joanna, Gonzalez-Aparicio, Manuela, Bravo-Perez, Carlos, Quetglas, Jose I., Carte, Beatriz, Gonzalez-Aseguinolaza, Gloria, Prieto, Jesus, Larrea, Esther, Hernandez-Alcoceba, Ruben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681018/
https://www.ncbi.nlm.nih.gov/pubmed/26671477
http://dx.doi.org/10.1186/s12943-015-0479-x

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