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Biological inflammatory markers mediate the effect of preoperative pain-related behaviours on postoperative analgesics requirements
BACKGROUND: The predictive value of an individual’s attitude towards painful situations and the status of his immune system for postoperative analgesic requirements are not well understood. These may help the clinician to anticipate individual patient’s needs. METHODS: Sixty patients, who underwent...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681155/ https://www.ncbi.nlm.nih.gov/pubmed/26674471 http://dx.doi.org/10.1186/s12871-015-0167-9 |
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author | Daoudia, Myriam Decruynaere, Céline Le Polain de Waroux, Bernard Thonnard, Jean-Louis Plaghki, Léon Forget, Patrice |
author_facet | Daoudia, Myriam Decruynaere, Céline Le Polain de Waroux, Bernard Thonnard, Jean-Louis Plaghki, Léon Forget, Patrice |
author_sort | Daoudia, Myriam |
collection | PubMed |
description | BACKGROUND: The predictive value of an individual’s attitude towards painful situations and the status of his immune system for postoperative analgesic requirements are not well understood. These may help the clinician to anticipate individual patient’s needs. METHODS: Sixty patients, who underwent a laparoscopic cholecystectomy under standardised general anaesthesia, were included. The total analgesic requirements during the first 48 h were the primary endpoint (unitary dosage, UD). The individual’s attitude towards imaginary painful situations was measured with the Situational Pain Scale (SPS). The emotional status was assessed by the Hospital Anxiety and Depression Scale (HADS) and the inflammatory status by the neutrophil-to-lymphocyte ratio (NLR). RESULTS: Univariate analyses revealed a significant association between UD and SPS, HADS and NLR. A negative relationship between SPS and NLR (NLR = 0.820–0.180*SPS;R(2) = 0.211;P < 0.001) and a positive relationship between SPS and HADS (HADS = 14.8 + 1.63*SPS; R(2) = 0.159;P = 0.002) were observed. A multiple linear regression analysis showed that the contribution of NLR to the UD was the most effective. A mediation analysis showed a complete mediation of the effect of SPS on UD (R(2) = 0.103;P = 0.012), by the NLR (SPS on NLR: R(2) = 0.211;P = <0.001), the HADS (SPS on HADS: R(2) = 0.159;P = 0.002). The variance in UD explained by the SPS was indirect and amounts to 46 % through NLR and to 34 % through HADS. CONCLUSIONS: In this series, preoperative pain-related attitudes (SPS) were associated with the postoperative analgesic requirements (UD) after a cholecystectomy. Eighty per cent of this effect was mediated by the HADS and the NLR. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12871-015-0167-9) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4681155 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-46811552015-12-17 Biological inflammatory markers mediate the effect of preoperative pain-related behaviours on postoperative analgesics requirements Daoudia, Myriam Decruynaere, Céline Le Polain de Waroux, Bernard Thonnard, Jean-Louis Plaghki, Léon Forget, Patrice BMC Anesthesiol Research Article BACKGROUND: The predictive value of an individual’s attitude towards painful situations and the status of his immune system for postoperative analgesic requirements are not well understood. These may help the clinician to anticipate individual patient’s needs. METHODS: Sixty patients, who underwent a laparoscopic cholecystectomy under standardised general anaesthesia, were included. The total analgesic requirements during the first 48 h were the primary endpoint (unitary dosage, UD). The individual’s attitude towards imaginary painful situations was measured with the Situational Pain Scale (SPS). The emotional status was assessed by the Hospital Anxiety and Depression Scale (HADS) and the inflammatory status by the neutrophil-to-lymphocyte ratio (NLR). RESULTS: Univariate analyses revealed a significant association between UD and SPS, HADS and NLR. A negative relationship between SPS and NLR (NLR = 0.820–0.180*SPS;R(2) = 0.211;P < 0.001) and a positive relationship between SPS and HADS (HADS = 14.8 + 1.63*SPS; R(2) = 0.159;P = 0.002) were observed. A multiple linear regression analysis showed that the contribution of NLR to the UD was the most effective. A mediation analysis showed a complete mediation of the effect of SPS on UD (R(2) = 0.103;P = 0.012), by the NLR (SPS on NLR: R(2) = 0.211;P = <0.001), the HADS (SPS on HADS: R(2) = 0.159;P = 0.002). The variance in UD explained by the SPS was indirect and amounts to 46 % through NLR and to 34 % through HADS. CONCLUSIONS: In this series, preoperative pain-related attitudes (SPS) were associated with the postoperative analgesic requirements (UD) after a cholecystectomy. Eighty per cent of this effect was mediated by the HADS and the NLR. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12871-015-0167-9) contains supplementary material, which is available to authorized users. BioMed Central 2015-12-16 /pmc/articles/PMC4681155/ /pubmed/26674471 http://dx.doi.org/10.1186/s12871-015-0167-9 Text en © Daoudia et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Daoudia, Myriam Decruynaere, Céline Le Polain de Waroux, Bernard Thonnard, Jean-Louis Plaghki, Léon Forget, Patrice Biological inflammatory markers mediate the effect of preoperative pain-related behaviours on postoperative analgesics requirements |
title | Biological inflammatory markers mediate the effect of preoperative pain-related behaviours on postoperative analgesics requirements |
title_full | Biological inflammatory markers mediate the effect of preoperative pain-related behaviours on postoperative analgesics requirements |
title_fullStr | Biological inflammatory markers mediate the effect of preoperative pain-related behaviours on postoperative analgesics requirements |
title_full_unstemmed | Biological inflammatory markers mediate the effect of preoperative pain-related behaviours on postoperative analgesics requirements |
title_short | Biological inflammatory markers mediate the effect of preoperative pain-related behaviours on postoperative analgesics requirements |
title_sort | biological inflammatory markers mediate the effect of preoperative pain-related behaviours on postoperative analgesics requirements |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681155/ https://www.ncbi.nlm.nih.gov/pubmed/26674471 http://dx.doi.org/10.1186/s12871-015-0167-9 |
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