Adult-born SVZ progenitors receive transient glutamatergic synapses during remyelination of the corpus callosum

We demonstrate that, after focal demyelination of adult mice corpus callosum, demyelinated axons form functional glutamatergic synapses onto adult-born NG2(+) oligodendrocyte progenitor cells (OPCs) migrating from the subventricular zone (SVZ). One week after lesion, this glutamatergic input is sign...

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Autores principales: Etxeberria, Ainhoa, Mangin, Jean-Marie, Aguirre, Adan, Gallo, Vittorio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681435/
https://www.ncbi.nlm.nih.gov/pubmed/20173746
http://dx.doi.org/10.1038/nn.2500
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author Etxeberria, Ainhoa
Mangin, Jean-Marie
Aguirre, Adan
Gallo, Vittorio
author_facet Etxeberria, Ainhoa
Mangin, Jean-Marie
Aguirre, Adan
Gallo, Vittorio
author_sort Etxeberria, Ainhoa
collection PubMed
description We demonstrate that, after focal demyelination of adult mice corpus callosum, demyelinated axons form functional glutamatergic synapses onto adult-born NG2(+) oligodendrocyte progenitor cells (OPCs) migrating from the subventricular zone (SVZ). One week after lesion, this glutamatergic input is significantly reduced compared to endogenous callosal OPCs, and is lost upon differentiation into oligodendrocytes. Therefore, axon-OP synapse formation is a transient and regulated step that occurs during remyelination of callosal axons.
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spelling pubmed-46814352015-12-16 Adult-born SVZ progenitors receive transient glutamatergic synapses during remyelination of the corpus callosum Etxeberria, Ainhoa Mangin, Jean-Marie Aguirre, Adan Gallo, Vittorio Nat Neurosci Article We demonstrate that, after focal demyelination of adult mice corpus callosum, demyelinated axons form functional glutamatergic synapses onto adult-born NG2(+) oligodendrocyte progenitor cells (OPCs) migrating from the subventricular zone (SVZ). One week after lesion, this glutamatergic input is significantly reduced compared to endogenous callosal OPCs, and is lost upon differentiation into oligodendrocytes. Therefore, axon-OP synapse formation is a transient and regulated step that occurs during remyelination of callosal axons. 2010-02-21 2010-03 /pmc/articles/PMC4681435/ /pubmed/20173746 http://dx.doi.org/10.1038/nn.2500 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Etxeberria, Ainhoa
Mangin, Jean-Marie
Aguirre, Adan
Gallo, Vittorio
Adult-born SVZ progenitors receive transient glutamatergic synapses during remyelination of the corpus callosum
title Adult-born SVZ progenitors receive transient glutamatergic synapses during remyelination of the corpus callosum
title_full Adult-born SVZ progenitors receive transient glutamatergic synapses during remyelination of the corpus callosum
title_fullStr Adult-born SVZ progenitors receive transient glutamatergic synapses during remyelination of the corpus callosum
title_full_unstemmed Adult-born SVZ progenitors receive transient glutamatergic synapses during remyelination of the corpus callosum
title_short Adult-born SVZ progenitors receive transient glutamatergic synapses during remyelination of the corpus callosum
title_sort adult-born svz progenitors receive transient glutamatergic synapses during remyelination of the corpus callosum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681435/
https://www.ncbi.nlm.nih.gov/pubmed/20173746
http://dx.doi.org/10.1038/nn.2500
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