Diterpenoids from the Roots of Salvia yunnanensis

ABSTRACT: Two new diterpenoids, salyunnanins I and J (1 and 2), together with ten analogues, were isolated from the roots of Salvia yunnanensis. The structures of the new isolates, possessing different neo-clerodane and seco-abietane diterpenoid skeletons respectively, were elucidated on the basis o...

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Detalles Bibliográficos
Autores principales: Xia, Fan, Wu, Chun-Yan, Yang, Xing-Wei, Li, Xian, Xu, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681706/
https://www.ncbi.nlm.nih.gov/pubmed/26667937
http://dx.doi.org/10.1007/s13659-015-0080-4
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author Xia, Fan
Wu, Chun-Yan
Yang, Xing-Wei
Li, Xian
Xu, Gang
author_facet Xia, Fan
Wu, Chun-Yan
Yang, Xing-Wei
Li, Xian
Xu, Gang
author_sort Xia, Fan
collection PubMed
description ABSTRACT: Two new diterpenoids, salyunnanins I and J (1 and 2), together with ten analogues, were isolated from the roots of Salvia yunnanensis. The structures of the new isolates, possessing different neo-clerodane and seco-abietane diterpenoid skeletons respectively, were elucidated on the basis of comprehensive spectroscopic data. All of the compounds were tested for the inhibitory activities against six human tumor lines in vitro, and several ones showed moderate cytotoxic activities. GRAPHICAL ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-015-0080-4) contains supplementary material, which is available to authorized users.
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spelling pubmed-46817062015-12-22 Diterpenoids from the Roots of Salvia yunnanensis Xia, Fan Wu, Chun-Yan Yang, Xing-Wei Li, Xian Xu, Gang Nat Prod Bioprospect Original Article ABSTRACT: Two new diterpenoids, salyunnanins I and J (1 and 2), together with ten analogues, were isolated from the roots of Salvia yunnanensis. The structures of the new isolates, possessing different neo-clerodane and seco-abietane diterpenoid skeletons respectively, were elucidated on the basis of comprehensive spectroscopic data. All of the compounds were tested for the inhibitory activities against six human tumor lines in vitro, and several ones showed moderate cytotoxic activities. GRAPHICAL ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-015-0080-4) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2015-12-14 /pmc/articles/PMC4681706/ /pubmed/26667937 http://dx.doi.org/10.1007/s13659-015-0080-4 Text en © The Author(s) 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Xia, Fan
Wu, Chun-Yan
Yang, Xing-Wei
Li, Xian
Xu, Gang
Diterpenoids from the Roots of Salvia yunnanensis
title Diterpenoids from the Roots of Salvia yunnanensis
title_full Diterpenoids from the Roots of Salvia yunnanensis
title_fullStr Diterpenoids from the Roots of Salvia yunnanensis
title_full_unstemmed Diterpenoids from the Roots of Salvia yunnanensis
title_short Diterpenoids from the Roots of Salvia yunnanensis
title_sort diterpenoids from the roots of salvia yunnanensis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681706/
https://www.ncbi.nlm.nih.gov/pubmed/26667937
http://dx.doi.org/10.1007/s13659-015-0080-4
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AT lixian diterpenoidsfromtherootsofsalviayunnanensis
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