The Effectiveness of Pemetrexed Monotherapy Depending on Polymorphisms in TS and MTHFR Genes as Well as Clinical Factors in Advanced NSCLC Patients

In NSCLC, second-line chemotherapy using pemetrexed or docetaxel has limited efficacy and should be dedicated to selected groups of patients. Pemetrexed is an antifolate compound with the ability to inhibit enzymes (TS, DHFR and GARFT) involved in pyrimidine and purine synthesis. The objective of th...

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Detalles Bibliográficos
Autores principales: Kucharczyk, Tomasz, Krawczyk, Paweł, Powrózek, Tomasz, Kowalski, Dariusz M., Ramlau, Rodryg, Kalinka-Warzocha, Ewa, Knetki-Wróblewska, Magdalena, Winiarczyk, Kinga, Krzakowski, Maciej, Milanowski, Janusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681747/
https://www.ncbi.nlm.nih.gov/pubmed/26277606
http://dx.doi.org/10.1007/s12253-015-9966-z

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