Epigenetic switch drives the conversion of fibroblasts into proinvasive cancer-associated fibroblasts

Carcinoma-associated fibroblasts (CAF) mediate the onset of a proinvasive tumour microenvironment. The proinflammatory cytokine LIF reprograms fibroblasts into a proinvasive phenotype, which promotes extracellular matrix remodelling and collective invasion of cancer cells. Here we unveil that exposu...

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Detalles Bibliográficos
Autores principales: Albrengues, Jean, Bertero, Thomas, Grasset, Eloise, Bonan, Stephanie, Maiel, Majdi, Bourget, Isabelle, Philippe, Claude, Herraiz Serrano, Cecilia, Benamar, Samia, Croce, Olivier, Sanz-Moreno, Victoria, Meneguzzi, Guerrino, Feral, Chloe C., Cristofari, Gael, Gaggioli, Cedric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682161/
https://www.ncbi.nlm.nih.gov/pubmed/26667266
http://dx.doi.org/10.1038/ncomms10204

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