Hypomethylation of smoking-related genes is associated with future lung cancer in four prospective cohorts

DNA hypomethylation in certain genes is associated with tobacco exposure but it is unknown whether these methylation changes translate into increased lung cancer risk. In an epigenome-wide study of DNA from pre-diagnostic blood samples from 132 case–control pairs in the NOWAC cohort, we observe that...

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Detalles Bibliográficos
Autores principales: Fasanelli, Francesca, Baglietto, Laura, Ponzi, Erica, Guida, Florence, Campanella, Gianluca, Johansson, Mattias, Grankvist, Kjell, Johansson, Mikael, Assumma, Manuela Bianca, Naccarati, Alessio, Chadeau-Hyam, Marc, Ala, Ugo, Faltus, Christian, Kaaks, Rudolf, Risch, Angela, De Stavola, Bianca, Hodge, Allison, Giles, Graham G., Southey, Melissa C., Relton, Caroline L., Haycock, Philip C., Lund, Eiliv, Polidoro, Silvia, Sandanger, Torkjel M., Severi, Gianluca, Vineis, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682166/
https://www.ncbi.nlm.nih.gov/pubmed/26667048
http://dx.doi.org/10.1038/ncomms10192

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