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Draxin from neocortical neurons controls the guidance of thalamocortical projections into the neocortex

The thalamocortical tract carries sensory information to the neocortex. It has long been recognized that the neocortical pioneer axons of subplate neurons are essential for thalamocortical development. Herein we report that an axon guidance cue, draxin, is expressed in early-born neocortical neurons...

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Autores principales: Shinmyo, Yohei, Asrafuzzaman Riyadh, M., Ahmed, Giasuddin, Bin Naser, Iftekhar, Hossain, Mahmud, Takebayashi, Hirohide, Kawasaki, Hiroshi, Ohta, Kunimasa, Tanaka, Hideaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682175/
https://www.ncbi.nlm.nih.gov/pubmed/26659141
http://dx.doi.org/10.1038/ncomms10232
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author Shinmyo, Yohei
Asrafuzzaman Riyadh, M.
Ahmed, Giasuddin
Bin Naser, Iftekhar
Hossain, Mahmud
Takebayashi, Hirohide
Kawasaki, Hiroshi
Ohta, Kunimasa
Tanaka, Hideaki
author_facet Shinmyo, Yohei
Asrafuzzaman Riyadh, M.
Ahmed, Giasuddin
Bin Naser, Iftekhar
Hossain, Mahmud
Takebayashi, Hirohide
Kawasaki, Hiroshi
Ohta, Kunimasa
Tanaka, Hideaki
author_sort Shinmyo, Yohei
collection PubMed
description The thalamocortical tract carries sensory information to the neocortex. It has long been recognized that the neocortical pioneer axons of subplate neurons are essential for thalamocortical development. Herein we report that an axon guidance cue, draxin, is expressed in early-born neocortical neurons, including subplate neurons, and is necessary for thalamocortical development. In draxin(−/−) mice, thalamocortical axons do not enter the neocortex. This phenotype is sufficiently rescued by the transgenic expression of draxin in neocortical neurons. Genetic interaction data suggest that draxin acts through Deleted in colorectal cancer (DCC) and Neogenin (Neo1), to regulate thalamocortical projections in vivo. Draxin promotes the outgrowth of thalamic axons in vitro and this effect is abolished in thalamic neurons from Dcc and Neo1 double mutants. These results suggest that draxin from neocortical neurons controls thalamocortical projections into the neocortex, and that this effect is mediated through the DCC and Neo1 receptors.
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spelling pubmed-46821752015-12-29 Draxin from neocortical neurons controls the guidance of thalamocortical projections into the neocortex Shinmyo, Yohei Asrafuzzaman Riyadh, M. Ahmed, Giasuddin Bin Naser, Iftekhar Hossain, Mahmud Takebayashi, Hirohide Kawasaki, Hiroshi Ohta, Kunimasa Tanaka, Hideaki Nat Commun Article The thalamocortical tract carries sensory information to the neocortex. It has long been recognized that the neocortical pioneer axons of subplate neurons are essential for thalamocortical development. Herein we report that an axon guidance cue, draxin, is expressed in early-born neocortical neurons, including subplate neurons, and is necessary for thalamocortical development. In draxin(−/−) mice, thalamocortical axons do not enter the neocortex. This phenotype is sufficiently rescued by the transgenic expression of draxin in neocortical neurons. Genetic interaction data suggest that draxin acts through Deleted in colorectal cancer (DCC) and Neogenin (Neo1), to regulate thalamocortical projections in vivo. Draxin promotes the outgrowth of thalamic axons in vitro and this effect is abolished in thalamic neurons from Dcc and Neo1 double mutants. These results suggest that draxin from neocortical neurons controls thalamocortical projections into the neocortex, and that this effect is mediated through the DCC and Neo1 receptors. Nature Publishing Group 2015-12-14 /pmc/articles/PMC4682175/ /pubmed/26659141 http://dx.doi.org/10.1038/ncomms10232 Text en Copyright © 2015, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Shinmyo, Yohei
Asrafuzzaman Riyadh, M.
Ahmed, Giasuddin
Bin Naser, Iftekhar
Hossain, Mahmud
Takebayashi, Hirohide
Kawasaki, Hiroshi
Ohta, Kunimasa
Tanaka, Hideaki
Draxin from neocortical neurons controls the guidance of thalamocortical projections into the neocortex
title Draxin from neocortical neurons controls the guidance of thalamocortical projections into the neocortex
title_full Draxin from neocortical neurons controls the guidance of thalamocortical projections into the neocortex
title_fullStr Draxin from neocortical neurons controls the guidance of thalamocortical projections into the neocortex
title_full_unstemmed Draxin from neocortical neurons controls the guidance of thalamocortical projections into the neocortex
title_short Draxin from neocortical neurons controls the guidance of thalamocortical projections into the neocortex
title_sort draxin from neocortical neurons controls the guidance of thalamocortical projections into the neocortex
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682175/
https://www.ncbi.nlm.nih.gov/pubmed/26659141
http://dx.doi.org/10.1038/ncomms10232
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