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Sulindac sulfide inhibits colon cancer cell growth and downregulates specificity protein transcription factors

BACKGROUND: Specificity protein (Sp) transcription factors play pivotal roles in maintaining the phenotypes of many cancers. We hypothesized that the antineoplastic effects of sulindac and its metabolites were due, in part, to targeting downregulation of Sp transcription factors. METHODS: The functi...

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Detalles Bibliográficos
Autores principales:	Li, Xi, Pathi, Satya S., Safe, Stephen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682223/ https://www.ncbi.nlm.nih.gov/pubmed/26673922 http://dx.doi.org/10.1186/s12885-015-1956-8

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