A polymorphism in the base excision repair gene PARP2 is associated with differential prognosis by chemotherapy among postmenopausal breast cancer patients

BACKGROUND: Personalized therapy considering clinical and genetic patient characteristics will further improve breast cancer survival. Two widely used treatments, chemotherapy and radiotherapy, can induce oxidative DNA damage and, if not repaired, cell death. Since base excision repair (BER) activit...

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Detalles Bibliográficos
Autores principales: Seibold, Petra, Schmezer, Peter, Behrens, Sabine, Michailidou, Kyriaki, Bolla, Manjeet K., Wang, Qin, Flesch-Janys, Dieter, Nevanlinna, Heli, Fagerholm, Rainer, Aittomäki, Kristiina, Blomqvist, Carl, Margolin, Sara, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli-Matti, Hartikainen, Jaana M., Lambrechts, Diether, Wildiers, Hans, Kristensen, Vessela, Alnæs, Grethe Grenaker, Nord, Silje, Borresen-Dale, Anne-Lise, Hooning, Maartje J., Hollestelle, Antoinette, Jager, Agnes, Seynaeve, Caroline, Li, Jingmei, Liu, Jianjun, Humphreys, Keith, Dunning, Alison M., Rhenius, Valerie, Shah, Mitul, Kabisch, Maria, Torres, Diana, Ulmer, Hans-Ulrich, Hamann, Ute, Schildkraut, Joellen M., Purrington, Kristen S., Couch, Fergus J., Hall, Per, Pharoah, Paul, Easton, Doug F., Schmidt, Marjanka K., Chang-Claude, Jenny, Popanda, Odilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682235/
https://www.ncbi.nlm.nih.gov/pubmed/26674097
http://dx.doi.org/10.1186/s12885-015-1957-7

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