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RUNX1-Evi-1 fusion gene inhibited differentiation and apoptosis in myelopoiesis: an in vivo study

BACKGROUND: Acute myeloid leukemia (AML) 1-Evi-1 is a chimeric gene generated by the t (3; 21) (q26; q22) translocation, which leads into malignant transformation of hematopoietic stem cells by unclear mechanisms. This in vivo study aimed to establish a stable line of zebrafish expressing the human...

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Detalles Bibliográficos
Autores principales:	Shen, Lijing, Zhu, Jianyi, Chen, Fangyuan, Lin, Wenjie, Cai, Jiayi, Zhong, Jihua, Zhong, Hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682245/ https://www.ncbi.nlm.nih.gov/pubmed/26674644 http://dx.doi.org/10.1186/s12885-015-1961-y

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