Genomic Analysis Reveals Disruption of Striatal Neuronal Development and Therapeutic Targets in Human Huntington’s Disease Neural Stem Cells

We utilized induced pluripotent stem cells (iPSCs) derived from Huntington’s disease (HD) patients as a human model of HD and determined that the disease phenotypes only manifest in the differentiated neural stem cell (NSC) stage, not in iPSCs. To understand the molecular basis for the CAG repeat ex...

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Detalles Bibliográficos
Autores principales: Ring, Karen L., An, Mahru C., Zhang, Ningzhe, O’Brien, Robert N., Ramos, Eliana Marisa, Gao, Fuying, Atwood, Robert, Bailus, Barbara J., Melov, Simon, Mooney, Sean D., Coppola, Giovanni, Ellerby, Lisa M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682390/
https://www.ncbi.nlm.nih.gov/pubmed/26651603
http://dx.doi.org/10.1016/j.stemcr.2015.11.005

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