Functional Complementation Assay for 47 MUTYH Variants in a MutY-Disrupted Escherichia Coli Strain

MUTYH-associated polyposis (MAP) is an adenomatous polyposis transmitted in an autosomal-recessive pattern, involving biallelic inactivation of the MUTYH gene. Loss of a functional MUTYH protein will result in the accumulation of G:T mismatched DNA caused by oxidative damage. Although p.Y179C and p....

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Detalles Bibliográficos
Autores principales: Komine, Keigo, Shimodaira, Hideki, Takao, Masashi, Soeda, Hiroshi, Zhang, Xiaofei, Takahashi, Masanobu, Ishioka, Chikashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682456/
https://www.ncbi.nlm.nih.gov/pubmed/25820570
http://dx.doi.org/10.1002/humu.22794

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