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Prognostic characteristics of duodenal gastrointestinal stromal tumours
BACKGROUND: This study evaluated the clinical characteristics, surgical procedures and prognosis of duodenal gastrointestinal stromal tumours (GISTs). METHODS: Patients with a diagnosis of primary duodenal GIST treated between January 2000 and December 2012 were analysed. Patients with gastric and s...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682471/ https://www.ncbi.nlm.nih.gov/pubmed/25980461 http://dx.doi.org/10.1002/bjs.9831 |
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author | Zhang, Q Shou, C-H Yu, J-R Yang, W-L Liu, X-S Yu, H Gao, Y Shen, Q-Y Zhao, Z-C |
author_facet | Zhang, Q Shou, C-H Yu, J-R Yang, W-L Liu, X-S Yu, H Gao, Y Shen, Q-Y Zhao, Z-C |
author_sort | Zhang, Q |
collection | PubMed |
description | BACKGROUND: This study evaluated the clinical characteristics, surgical procedures and prognosis of duodenal gastrointestinal stromal tumours (GISTs). METHODS: Patients with a diagnosis of primary duodenal GIST treated between January 2000 and December 2012 were analysed. Patients with gastric and small intestinal GISTs were chosen as control groups according to the following parameters: age, tumour size, mitotic index and adjuvant imatinib therapy. Operative procedures for patients with duodenal GIST included pancreaticoduodenectomy or limited resection. Disease-free survival (DFS) was calculated using Kaplan–Meier analysis. RESULTS: Some 71 patients with duodenal, 71 with gastric and 70 with small intestinal GISTs were included in the study. DFS of patients with duodenal GIST was shorter than that of patients with gastric GIST (3-year DFS 84 versus 94 per cent; hazard ratio (HR) 3.67, 95 per cent c.i. 1.21 to 11.16; P = 0.014), but was similar to that of patients with small intestinal GIST (3-year DFS 84 versus 81 per cent; HR 0.75, 0.37 to 1.51; P = 0.491). Patients who underwent pancreaticoduodenectomy were older, and had larger tumours and a higher mitotic index than patients who had limited resection. The 3-year DFS was 93 per cent among patients who had limited resection compared with 64 per cent for those who underwent PD (HR 0.18, 0.06 to 0.59; P = 0.001). CONCLUSION: The prognosis of duodenal GISTs is similar to that of small intestinal GISTs. Prognosis no different than for small bowel gastrointestinal stromal tumours |
format | Online Article Text |
id | pubmed-4682471 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | John Wiley & Sons, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-46824712015-12-23 Prognostic characteristics of duodenal gastrointestinal stromal tumours Zhang, Q Shou, C-H Yu, J-R Yang, W-L Liu, X-S Yu, H Gao, Y Shen, Q-Y Zhao, Z-C Br J Surg Original Articles BACKGROUND: This study evaluated the clinical characteristics, surgical procedures and prognosis of duodenal gastrointestinal stromal tumours (GISTs). METHODS: Patients with a diagnosis of primary duodenal GIST treated between January 2000 and December 2012 were analysed. Patients with gastric and small intestinal GISTs were chosen as control groups according to the following parameters: age, tumour size, mitotic index and adjuvant imatinib therapy. Operative procedures for patients with duodenal GIST included pancreaticoduodenectomy or limited resection. Disease-free survival (DFS) was calculated using Kaplan–Meier analysis. RESULTS: Some 71 patients with duodenal, 71 with gastric and 70 with small intestinal GISTs were included in the study. DFS of patients with duodenal GIST was shorter than that of patients with gastric GIST (3-year DFS 84 versus 94 per cent; hazard ratio (HR) 3.67, 95 per cent c.i. 1.21 to 11.16; P = 0.014), but was similar to that of patients with small intestinal GIST (3-year DFS 84 versus 81 per cent; HR 0.75, 0.37 to 1.51; P = 0.491). Patients who underwent pancreaticoduodenectomy were older, and had larger tumours and a higher mitotic index than patients who had limited resection. The 3-year DFS was 93 per cent among patients who had limited resection compared with 64 per cent for those who underwent PD (HR 0.18, 0.06 to 0.59; P = 0.001). CONCLUSION: The prognosis of duodenal GISTs is similar to that of small intestinal GISTs. Prognosis no different than for small bowel gastrointestinal stromal tumours John Wiley & Sons, Ltd 2015-07 2015-05-18 /pmc/articles/PMC4682471/ /pubmed/25980461 http://dx.doi.org/10.1002/bjs.9831 Text en © 2015 The Authors. BJS published by John Wiley & Sons Ltd on behalf of BJS Society Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Original Articles Zhang, Q Shou, C-H Yu, J-R Yang, W-L Liu, X-S Yu, H Gao, Y Shen, Q-Y Zhao, Z-C Prognostic characteristics of duodenal gastrointestinal stromal tumours |
title | Prognostic characteristics of duodenal gastrointestinal stromal tumours |
title_full | Prognostic characteristics of duodenal gastrointestinal stromal tumours |
title_fullStr | Prognostic characteristics of duodenal gastrointestinal stromal tumours |
title_full_unstemmed | Prognostic characteristics of duodenal gastrointestinal stromal tumours |
title_short | Prognostic characteristics of duodenal gastrointestinal stromal tumours |
title_sort | prognostic characteristics of duodenal gastrointestinal stromal tumours |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682471/ https://www.ncbi.nlm.nih.gov/pubmed/25980461 http://dx.doi.org/10.1002/bjs.9831 |
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