Modulation of TREM2 by CD33: a protein QTL study integrates Alzheimer loci in human monocytes

Here, we report results from a protein quantitative trait analysis in monocytes from 226 individuals to evaluate cross-talk between Alzheimer loci. We find that the NME8 locus influences PTK2B and that the CD33 risk allele leads to greater TREM2 expression. Further, we observe (1) a decreased TREM1/...

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Autores principales: Chan, Gail, White, Charles C., Winn, Phoebe A., Cimpean, Maria, Replogle, Joseph M., Glick, Laura R., Cuerdon, Nicole E., Ryan, Katie J., Johnson, Keith A., Schneider, Julie A., Bennett, David A., Chibnik, Lori B., Sperling, Reisa A., Bradshaw, Elizabeth M., De Jager, Philip L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682915/
https://www.ncbi.nlm.nih.gov/pubmed/26414614
http://dx.doi.org/10.1038/nn.4126
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author Chan, Gail
White, Charles C.
Winn, Phoebe A.
Cimpean, Maria
Replogle, Joseph M.
Glick, Laura R.
Cuerdon, Nicole E.
Ryan, Katie J.
Johnson, Keith A.
Schneider, Julie A.
Bennett, David A.
Chibnik, Lori B.
Sperling, Reisa A.
Bradshaw, Elizabeth M.
De Jager, Philip L.
author_facet Chan, Gail
White, Charles C.
Winn, Phoebe A.
Cimpean, Maria
Replogle, Joseph M.
Glick, Laura R.
Cuerdon, Nicole E.
Ryan, Katie J.
Johnson, Keith A.
Schneider, Julie A.
Bennett, David A.
Chibnik, Lori B.
Sperling, Reisa A.
Bradshaw, Elizabeth M.
De Jager, Philip L.
author_sort Chan, Gail
collection PubMed
description Here, we report results from a protein quantitative trait analysis in monocytes from 226 individuals to evaluate cross-talk between Alzheimer loci. We find that the NME8 locus influences PTK2B and that the CD33 risk allele leads to greater TREM2 expression. Further, we observe (1) a decreased TREM1/TREM2 ratio with a TREM1 risk allele, (2) decreased TREM2 expression with CD33 suppression, and (3) elevated cortical TREM2 mRNA expression with amyloid pathology.
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spelling pubmed-46829152016-05-01 Modulation of TREM2 by CD33: a protein QTL study integrates Alzheimer loci in human monocytes Chan, Gail White, Charles C. Winn, Phoebe A. Cimpean, Maria Replogle, Joseph M. Glick, Laura R. Cuerdon, Nicole E. Ryan, Katie J. Johnson, Keith A. Schneider, Julie A. Bennett, David A. Chibnik, Lori B. Sperling, Reisa A. Bradshaw, Elizabeth M. De Jager, Philip L. Nat Neurosci Article Here, we report results from a protein quantitative trait analysis in monocytes from 226 individuals to evaluate cross-talk between Alzheimer loci. We find that the NME8 locus influences PTK2B and that the CD33 risk allele leads to greater TREM2 expression. Further, we observe (1) a decreased TREM1/TREM2 ratio with a TREM1 risk allele, (2) decreased TREM2 expression with CD33 suppression, and (3) elevated cortical TREM2 mRNA expression with amyloid pathology. 2015-09-28 2015-11 /pmc/articles/PMC4682915/ /pubmed/26414614 http://dx.doi.org/10.1038/nn.4126 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Chan, Gail
White, Charles C.
Winn, Phoebe A.
Cimpean, Maria
Replogle, Joseph M.
Glick, Laura R.
Cuerdon, Nicole E.
Ryan, Katie J.
Johnson, Keith A.
Schneider, Julie A.
Bennett, David A.
Chibnik, Lori B.
Sperling, Reisa A.
Bradshaw, Elizabeth M.
De Jager, Philip L.
Modulation of TREM2 by CD33: a protein QTL study integrates Alzheimer loci in human monocytes
title Modulation of TREM2 by CD33: a protein QTL study integrates Alzheimer loci in human monocytes
title_full Modulation of TREM2 by CD33: a protein QTL study integrates Alzheimer loci in human monocytes
title_fullStr Modulation of TREM2 by CD33: a protein QTL study integrates Alzheimer loci in human monocytes
title_full_unstemmed Modulation of TREM2 by CD33: a protein QTL study integrates Alzheimer loci in human monocytes
title_short Modulation of TREM2 by CD33: a protein QTL study integrates Alzheimer loci in human monocytes
title_sort modulation of trem2 by cd33: a protein qtl study integrates alzheimer loci in human monocytes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682915/
https://www.ncbi.nlm.nih.gov/pubmed/26414614
http://dx.doi.org/10.1038/nn.4126
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