Modulation of TREM2 by CD33: a protein QTL study integrates Alzheimer loci in human monocytes

Here, we report results from a protein quantitative trait analysis in monocytes from 226 individuals to evaluate cross-talk between Alzheimer loci. We find that the NME8 locus influences PTK2B and that the CD33 risk allele leads to greater TREM2 expression. Further, we observe (1) a decreased TREM1/...

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Detalles Bibliográficos
Autores principales: Chan, Gail, White, Charles C., Winn, Phoebe A., Cimpean, Maria, Replogle, Joseph M., Glick, Laura R., Cuerdon, Nicole E., Ryan, Katie J., Johnson, Keith A., Schneider, Julie A., Bennett, David A., Chibnik, Lori B., Sperling, Reisa A., Bradshaw, Elizabeth M., De Jager, Philip L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682915/
https://www.ncbi.nlm.nih.gov/pubmed/26414614
http://dx.doi.org/10.1038/nn.4126

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