GDNF Overexpression from the Native Locus Reveals its Role in the Nigrostriatal Dopaminergic System Function

Degeneration of nigrostriatal dopaminergic system is the principal lesion in Parkinson’s disease. Because glial cell line-derived neurotrophic factor (GDNF) promotes survival of dopamine neurons in vitro and in vivo, intracranial delivery of GDNF has been attempted for Parkinson’s disease treatment...

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Detalles Bibliográficos
Autores principales: Kumar, Anmol, Kopra, Jaakko, Varendi, Kärt, Porokuokka, Lauriina L., Panhelainen, Anne, Kuure, Satu, Marshall, Pepin, Karalija, Nina, Härma, Mari-Anne, Vilenius, Carolina, Lilleväli, Kersti, Tekko, Triin, Mijatovic, Jelena, Pulkkinen, Nita, Jakobson, Madis, Jakobson, Maili, Ola, Roxana, Palm, Erik, Lindahl, Maria, Strömberg, Ingrid, Võikar, Vootele, Piepponen, T. Petteri, Saarma, Mart, Andressoo, Jaan-Olle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682981/
https://www.ncbi.nlm.nih.gov/pubmed/26681446
http://dx.doi.org/10.1371/journal.pgen.1005710

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