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γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP)

The relative increase in Aβ42 peptides from familial Alzheimer disease (FAD) linked APP and PSEN mutations can be related to changes in both ε-cleavage site utilization and subsequent step-wise cleavage. Cleavage at the ε-site releases the amyloid precursor protein (APP) intracellular domain (AICD),...

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Detalles Bibliográficos
Autores principales:	Lessard, Christian B., Cottrell, Barbara A., Maruyama, Hiroko, Suresh, Suraj, Golde, Todd E., Koo, Edward H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683055/ https://www.ncbi.nlm.nih.gov/pubmed/26678856 http://dx.doi.org/10.1371/journal.pone.0144758

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