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Structure-based Discovery of Novel Small Molecule Wnt Signaling Inhibitors by Targeting the Cysteine-rich Domain of Frizzled

Frizzled is the earliest discovered glycosylated Wnt protein receptor and is critical for the initiation of Wnt signaling. Antagonizing Frizzled is effective in inhibiting the growth of multiple tumor types. The extracellular N terminus of Frizzled contains a conserved cysteine-rich domain that dire...

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Detalles Bibliográficos
Autores principales:	Lee, Ho-Jin, Bao, Ju, Miller, Ami, Zhang, Chi, Wu, Jibo, Baday, Yiressy C., Guibao, Cristina, Li, Lin, Wu, Dianqing, Zheng, Jie J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2015
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683279/ https://www.ncbi.nlm.nih.gov/pubmed/26504084 http://dx.doi.org/10.1074/jbc.M115.673202

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