Cysteines 208 and 241 in Ero1α are required for maximal catalytic turnover

Endoplasmic reticulum (ER) oxidoreductin 1α (Ero1α) is a disulfide producer in the ER of mammalian cells. Besides four catalytic cysteines (Cys(94), Cys(99), Cys(394), Cys(397)), Ero1α harbors four regulatory cysteines (Cys(104), Cys(131), Cys(208), Cys(241)). These cysteines mediate the formation o...

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Detalles Bibliográficos
Autores principales: Ramming, Thomas, Kanemura, Shingo, Okumura, Masaki, Inaba, Kenji, Appenzeller-Herzog, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683387/
https://www.ncbi.nlm.nih.gov/pubmed/26609561
http://dx.doi.org/10.1016/j.redox.2015.11.004

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