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Mechanism for attenuated outward conductance induced by mutations in the cytoplasmic pore of Kir2.1 channels
Outward currents through Kir2.1 channels regulate the electrical properties of excitable cells. These currents are subject to voltage-dependent attenuation by the binding of polyamines to high- and low-affinity sites, which leads to inward rectification, thereby controlling cell excitability. To exa...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683409/ https://www.ncbi.nlm.nih.gov/pubmed/26678093 http://dx.doi.org/10.1038/srep18404 |