Deletion of GSTA4-4 results in increased mitochondrial post-translational modification of proteins by reactive aldehydes following chronic ethanol consumption in mice

Chronic alcohol consumption induces hepatic oxidative stress resulting in production of highly reactive electrophilic α/β-unsaturated aldehydes that have the potential to modify proteins. A primary mechanism of reactive aldehyde detoxification by hepatocytes is through GSTA4-driven enzymatic conjuga...

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Detalles Bibliográficos
Autores principales: Shearn, Colin T., Fritz, Kristofer S., Shearn, Alisabeth H., Saba, Laura M., Mercer, Kelly E., Engi, Bridgette, Galligan, James J., Zimniak, Piotr, Orlicky, David J., Ronis, Martin J., Petersen, Dennis R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683459/
https://www.ncbi.nlm.nih.gov/pubmed/26654979
http://dx.doi.org/10.1016/j.redox.2015.11.013

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