Convulsions following rapid ceftazidime administration for preinduction antibiotic prophylaxis during neurosurgical procedure

Ceftazidime is a widely used antibiotic with broad spectrum activity against Gram-positive and Gram-negative microbes and is used prophylactically in neurosurgical patients prior to surgery. Neurotoxicity is a recognized complication of ceftazidime use but is reported predominantly after repeated ad...

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Autores principales: Haldar, Rudrashish, Kaushal, Ashutosh, Gupta, Devendra, Srivastava, Shashi, Singh, Prabhat K., Ambesh, Paurush
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683498/
https://www.ncbi.nlm.nih.gov/pubmed/26712990
http://dx.doi.org/10.4103/0259-1162.159773
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author Haldar, Rudrashish
Kaushal, Ashutosh
Gupta, Devendra
Srivastava, Shashi
Singh, Prabhat K.
Ambesh, Paurush
author_facet Haldar, Rudrashish
Kaushal, Ashutosh
Gupta, Devendra
Srivastava, Shashi
Singh, Prabhat K.
Ambesh, Paurush
author_sort Haldar, Rudrashish
collection PubMed
description Ceftazidime is a widely used antibiotic with broad spectrum activity against Gram-positive and Gram-negative microbes and is used prophylactically in neurosurgical patients prior to surgery. Neurotoxicity is a recognized complication of ceftazidime use but is reported predominantly after repeated administration in patients with impaired renal status. We encountered a patient with an intracranial tumor who developed generalized convulsions following a single dose of ceftazidime, which was infused rapidly and attempt to provide an explanation of this uncommon occurrence.
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spelling pubmed-46834982015-12-28 Convulsions following rapid ceftazidime administration for preinduction antibiotic prophylaxis during neurosurgical procedure Haldar, Rudrashish Kaushal, Ashutosh Gupta, Devendra Srivastava, Shashi Singh, Prabhat K. Ambesh, Paurush Anesth Essays Res Case Report Ceftazidime is a widely used antibiotic with broad spectrum activity against Gram-positive and Gram-negative microbes and is used prophylactically in neurosurgical patients prior to surgery. Neurotoxicity is a recognized complication of ceftazidime use but is reported predominantly after repeated administration in patients with impaired renal status. We encountered a patient with an intracranial tumor who developed generalized convulsions following a single dose of ceftazidime, which was infused rapidly and attempt to provide an explanation of this uncommon occurrence. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4683498/ /pubmed/26712990 http://dx.doi.org/10.4103/0259-1162.159773 Text en Copyright: © 2015 Anesthesia: Essays and Researches http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Case Report
Haldar, Rudrashish
Kaushal, Ashutosh
Gupta, Devendra
Srivastava, Shashi
Singh, Prabhat K.
Ambesh, Paurush
Convulsions following rapid ceftazidime administration for preinduction antibiotic prophylaxis during neurosurgical procedure
title Convulsions following rapid ceftazidime administration for preinduction antibiotic prophylaxis during neurosurgical procedure
title_full Convulsions following rapid ceftazidime administration for preinduction antibiotic prophylaxis during neurosurgical procedure
title_fullStr Convulsions following rapid ceftazidime administration for preinduction antibiotic prophylaxis during neurosurgical procedure
title_full_unstemmed Convulsions following rapid ceftazidime administration for preinduction antibiotic prophylaxis during neurosurgical procedure
title_short Convulsions following rapid ceftazidime administration for preinduction antibiotic prophylaxis during neurosurgical procedure
title_sort convulsions following rapid ceftazidime administration for preinduction antibiotic prophylaxis during neurosurgical procedure
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683498/
https://www.ncbi.nlm.nih.gov/pubmed/26712990
http://dx.doi.org/10.4103/0259-1162.159773
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