Cancer associated missense mutations in BAP1 catalytic domain induce amyloidogenic aggregation: A new insight in enzymatic inactivation

BRCA1 associated protein 1 (BAP1) is a nuclear deubiquitinase that regulates tumor suppressor activity and widely involves many cellular processes ranging from cell cycle regulation to gluconeogenesis. Impairment of enzymatic activity and nuclear localization induce abnormal cell proliferation. It i...

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Detalles Bibliográficos
Autores principales: Bhattacharya, Sushmita, Hanpude, Pranita, Maiti, Tushar Kanti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683529/
https://www.ncbi.nlm.nih.gov/pubmed/26680512
http://dx.doi.org/10.1038/srep18462

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683529/
https://www.ncbi.nlm.nih.gov/pubmed/26680512
http://dx.doi.org/10.1038/srep18462

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