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Kinetic response of wild and mutant core codon 70 strains of HCV genotype 1b to pegylated interferon-α and ribavirin therapy

BACKGROUND: Amino acid (aa) 70 substitution (R70Q/H) in the core protein of hepatitis C virus (HCV) genotype 1b has been shown to be one of the key factors in determining resistance for pegylated interferon-α plus ribavirin combination therapy (PEG-IFNα/RBV). But the exact mechanisms remain unclear....

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Detalles Bibliográficos
Autores principales:	Hu, Zhongjie, Liu, Ying, Qiu, Lixia, Fan, Zuopeng, Nie, Wei, Liang, Shan, Jin, Ronghua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683707/ https://www.ncbi.nlm.nih.gov/pubmed/26684004 http://dx.doi.org/10.1186/s12985-015-0451-9

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