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Analysis of surgery for incurable gastric cancer

BACKGROUND: It is important to evaluate the curability of and avoid unnecessary exploratory surgery for gastric cancer preoperatively. However, no related research has been reported until now. The aim of this study was to evaluate the factors influencing surgery for incurable gastric cancer. METHODS...

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Autores principales: Zhao, Honguang, Chen, Wenhu, Lin, Yehua, Qin, Jiangfeng, Wang, Lifang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683841/
https://www.ncbi.nlm.nih.gov/pubmed/26684015
http://dx.doi.org/10.1186/s12957-015-0750-z
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author Zhao, Honguang
Chen, Wenhu
Lin, Yehua
Qin, Jiangfeng
Wang, Lifang
author_facet Zhao, Honguang
Chen, Wenhu
Lin, Yehua
Qin, Jiangfeng
Wang, Lifang
author_sort Zhao, Honguang
collection PubMed
description BACKGROUND: It is important to evaluate the curability of and avoid unnecessary exploratory surgery for gastric cancer preoperatively. However, no related research has been reported until now. The aim of this study was to evaluate the factors influencing surgery for incurable gastric cancer. METHODS: 310 cases of T3–4 gastric cancer patients were analyzed retrospectively, including 141 cases with radical surgery and 169 with surgery for incurable gastric cancer. The incurable factors were categorized as T status (unresectable T4 tumor), N status (unresectable lymph node), peritoneal metastasis, and distant metastasis. χ(2) test and logistic regression were performed to analyze the associations between curability, T status, N status, peritoneal metastasis, or distant metastasis and clinicopathological data. RESULTS: Esophageal involvement and T grade were associated with curability. Cardia involvement and Borrmann type were associated with T status. Esophageal involvement and T grade were associated with N status. Gastric body involvement, esophageal involvement, and T grade were associated with peritoneal metastasis. Gastric antrum involvement was associated with distant metastasis. CONCLUSIONS: The influencing factors of surgery for incurable gastric cancer should be analyzed preoperatively. Resectability should be evaluated according to these influencing factors combined with imaging analysis.
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spelling pubmed-46838412015-12-19 Analysis of surgery for incurable gastric cancer Zhao, Honguang Chen, Wenhu Lin, Yehua Qin, Jiangfeng Wang, Lifang World J Surg Oncol Research BACKGROUND: It is important to evaluate the curability of and avoid unnecessary exploratory surgery for gastric cancer preoperatively. However, no related research has been reported until now. The aim of this study was to evaluate the factors influencing surgery for incurable gastric cancer. METHODS: 310 cases of T3–4 gastric cancer patients were analyzed retrospectively, including 141 cases with radical surgery and 169 with surgery for incurable gastric cancer. The incurable factors were categorized as T status (unresectable T4 tumor), N status (unresectable lymph node), peritoneal metastasis, and distant metastasis. χ(2) test and logistic regression were performed to analyze the associations between curability, T status, N status, peritoneal metastasis, or distant metastasis and clinicopathological data. RESULTS: Esophageal involvement and T grade were associated with curability. Cardia involvement and Borrmann type were associated with T status. Esophageal involvement and T grade were associated with N status. Gastric body involvement, esophageal involvement, and T grade were associated with peritoneal metastasis. Gastric antrum involvement was associated with distant metastasis. CONCLUSIONS: The influencing factors of surgery for incurable gastric cancer should be analyzed preoperatively. Resectability should be evaluated according to these influencing factors combined with imaging analysis. BioMed Central 2015-12-18 /pmc/articles/PMC4683841/ /pubmed/26684015 http://dx.doi.org/10.1186/s12957-015-0750-z Text en © Zhao et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Zhao, Honguang
Chen, Wenhu
Lin, Yehua
Qin, Jiangfeng
Wang, Lifang
Analysis of surgery for incurable gastric cancer
title Analysis of surgery for incurable gastric cancer
title_full Analysis of surgery for incurable gastric cancer
title_fullStr Analysis of surgery for incurable gastric cancer
title_full_unstemmed Analysis of surgery for incurable gastric cancer
title_short Analysis of surgery for incurable gastric cancer
title_sort analysis of surgery for incurable gastric cancer
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683841/
https://www.ncbi.nlm.nih.gov/pubmed/26684015
http://dx.doi.org/10.1186/s12957-015-0750-z
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