Pro-inflammatory pattern of IgG1 Fc glycosylation in multiple sclerosis cerebrospinal fluid

BACKGROUND: Immunoglobulin G (IgG) effector functions are regulated by the composition of glycans attached to a conserved N-glycosylation site in the Fc part. Intrathecal production of IgG, especially IgG1, is a hallmark of multiple sclerosis (MS), but nothing is known about IgG Fc glycosylation in...

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Detalles Bibliográficos
Autores principales: Wuhrer, Manfred, Selman, Maurice H. J., McDonnell, Liam A., Kümpfel, Tania, Derfuss, Tobias, Khademi, Mohsen, Olsson, Tomas, Hohlfeld, Reinhard, Meinl, Edgar, Krumbholz, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683913/
https://www.ncbi.nlm.nih.gov/pubmed/26683050
http://dx.doi.org/10.1186/s12974-015-0450-1

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