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Histological investigation of the impact of streptozotocin-induced experimental diabetes on the healthy gingivae of rats
This study was aimed at the histological investigation of the impact of experimental diabetes on the healthy gingiva of rats. Thirty male Wistar rats were used in this study. The animals were randomly divided into two groups (n = 15) prior to the experiment. Group 1 experimental diabetes was created...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684055/ https://www.ncbi.nlm.nih.gov/pubmed/26740771 http://dx.doi.org/10.1080/13102818.2014.943558 |
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author | Dağ, Ahmet Tules Fırat, Ela Uysal, Ersin Ketani, Şennur Aydın Ketani, Muzaffer |
author_facet | Dağ, Ahmet Tules Fırat, Ela Uysal, Ersin Ketani, Şennur Aydın Ketani, Muzaffer |
author_sort | Dağ, Ahmet |
collection | PubMed |
description | This study was aimed at the histological investigation of the impact of experimental diabetes on the healthy gingiva of rats. Thirty male Wistar rats were used in this study. The animals were randomly divided into two groups (n = 15) prior to the experiment. Group 1 experimental diabetes was created by streptozotocin injection in 15 rats. Group 2 comprised the control group (15 rats). On the 7th, 14th and 21st days after the induction of diabetes by streptozotocin, five animals from each group were euthanized by cardiac puncture. The gingiva of the maxillary left first molar tooth of the sacrificed animals was extracted for histological examination. Histological examination demonstrated that, when compared to the control group, the diabetes group displayed marked hyperkeratosis and parakeratosis of the gingival epithelium on day 21 post-induction. Furthermore, the diabetes group presented with an increased number of inflammatory cells and vasodilatation of the capillaries, in comparison to the controls. The overall evaluation of the findings obtained in this study suggested that diabetes alone could cause changes in the periodontium and affect periodontal health. |
format | Online Article Text |
id | pubmed-4684055 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-46840552016-01-04 Histological investigation of the impact of streptozotocin-induced experimental diabetes on the healthy gingivae of rats Dağ, Ahmet Tules Fırat, Ela Uysal, Ersin Ketani, Şennur Aydın Ketani, Muzaffer Biotechnol Biotechnol Equip Article; Medical Biotechnology This study was aimed at the histological investigation of the impact of experimental diabetes on the healthy gingiva of rats. Thirty male Wistar rats were used in this study. The animals were randomly divided into two groups (n = 15) prior to the experiment. Group 1 experimental diabetes was created by streptozotocin injection in 15 rats. Group 2 comprised the control group (15 rats). On the 7th, 14th and 21st days after the induction of diabetes by streptozotocin, five animals from each group were euthanized by cardiac puncture. The gingiva of the maxillary left first molar tooth of the sacrificed animals was extracted for histological examination. Histological examination demonstrated that, when compared to the control group, the diabetes group displayed marked hyperkeratosis and parakeratosis of the gingival epithelium on day 21 post-induction. Furthermore, the diabetes group presented with an increased number of inflammatory cells and vasodilatation of the capillaries, in comparison to the controls. The overall evaluation of the findings obtained in this study suggested that diabetes alone could cause changes in the periodontium and affect periodontal health. Taylor & Francis 2014-07-04 2014-10-17 /pmc/articles/PMC4684055/ /pubmed/26740771 http://dx.doi.org/10.1080/13102818.2014.943558 Text en © 2014 The Author(s). Published by Taylor & Francis. http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted. |
spellingShingle | Article; Medical Biotechnology Dağ, Ahmet Tules Fırat, Ela Uysal, Ersin Ketani, Şennur Aydın Ketani, Muzaffer Histological investigation of the impact of streptozotocin-induced experimental diabetes on the healthy gingivae of rats |
title | Histological investigation of the impact of streptozotocin-induced experimental diabetes on the healthy gingivae of rats |
title_full | Histological investigation of the impact of streptozotocin-induced experimental diabetes on the healthy gingivae of rats |
title_fullStr | Histological investigation of the impact of streptozotocin-induced experimental diabetes on the healthy gingivae of rats |
title_full_unstemmed | Histological investigation of the impact of streptozotocin-induced experimental diabetes on the healthy gingivae of rats |
title_short | Histological investigation of the impact of streptozotocin-induced experimental diabetes on the healthy gingivae of rats |
title_sort | histological investigation of the impact of streptozotocin-induced experimental diabetes on the healthy gingivae of rats |
topic | Article; Medical Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684055/ https://www.ncbi.nlm.nih.gov/pubmed/26740771 http://dx.doi.org/10.1080/13102818.2014.943558 |
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