Knock-down of pantothenate kinase 2 severely affects the development of the nervous and vascular system in zebrafish, providing new insights into PKAN disease

Pantothenate Kinase Associated Neurodegeneration (PKAN) is an autosomal recessive disorder with mutations in the pantothenate kinase 2 gene (PANK2), encoding an essential enzyme for Coenzyme A (CoA) biosynthesis. The molecular connection between defects in this enzyme and the neurodegenerative pheno...

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Detalles Bibliográficos
Autores principales: Zizioli, Daniela, Tiso, Natascia, Guglielmi, Adele, Saraceno, Claudia, Busolin, Giorgia, Giuliani, Roberta, Khatri, Deepak, Monti, Eugenio, Borsani, Giuseppe, Argenton, Francesco, Finazzi, Dario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684146/
https://www.ncbi.nlm.nih.gov/pubmed/26476142
http://dx.doi.org/10.1016/j.nbd.2015.10.010

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