EEPD1 Rescues Stressed Replication Forks and Maintains Genome Stability by Promoting End Resection and Homologous Recombination Repair

Replication fork stalling and collapse is a major source of genome instability leading to neoplastic transformation or cell death. Such stressed replication forks can be conservatively repaired and restarted using homologous recombination (HR) or non-conservatively repaired using micro-homology medi...

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Detalles Bibliográficos
Autores principales: Wu, Yuehan, Lee, Suk-Hee, Williamson, Elizabeth A., Reinert, Brian L., Cho, Ju Hwan, Xia, Fen, Jaiswal, Aruna Shanker, Srinivasan, Gayathri, Patel, Bhavita, Brantley, Alexis, Zhou, Daohong, Shao, Lijian, Pathak, Rupak, Hauer-Jensen, Martin, Singh, Sudha, Kong, Kimi, Wu, Xaiohua, Kim, Hyun-Suk, Beissbarth, Timothy, Gaedcke, Jochen, Burma, Sandeep, Nickoloff, Jac A., Hromas, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684289/
https://www.ncbi.nlm.nih.gov/pubmed/26684013
http://dx.doi.org/10.1371/journal.pgen.1005675

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