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Prestin-Dependence of Outer Hair Cell Survival and Partial Rescue of Outer Hair Cell Loss in Prestin (V499G/Y501H) Knockin Mice

A knockin (KI) mouse expressing mutated prestin (V499G/Y501H) (499 prestin) was created to study cochlear amplification. Recordings from isolated outer hair cells (OHC) in this mutant showed vastly reduced electromotility and, as a consequence, reduced hearing sensitivity. Although 499 prestin OHCs...

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Detalles Bibliográficos
Autores principales:	Cheatham, Mary Ann, Edge, Roxanne M., Homma, Kazuaki, Leserman, Emily L., Dallos, Peter, Zheng, Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684303/ https://www.ncbi.nlm.nih.gov/pubmed/26682723 http://dx.doi.org/10.1371/journal.pone.0145428

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