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New Infestin-4 Mutants with Increased Selectivity against Factor XIIa

Factor XIIa (fXIIa) is a serine protease that triggers the coagulation contact pathway and plays a role in thrombosis. Because it interferes with coagulation testing, the need to inhibit fXIIa exists in many cases. Infestin-4 (Inf4) is a Kazal-type inhibitor of fXIIa. Its specificity for fXIIa can b...

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Detalles Bibliográficos
Autores principales:	Kolyadko, Vladimir N., Lushchekina, Sofya V., Vuimo, Tatiana A., Surov, Stepan S., Ovsepyan, Ruzanna A., Korneeva, Vera A., Vorobiev, Ivan I., Orlova, Nadezhda A., Minakhin, Leonid, Kuznedelov, Konstantin, Severinov, Konstantin V., Ataullakhanov, Fazoil I., Panteleev, Mikhail A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684401/ https://www.ncbi.nlm.nih.gov/pubmed/26670620 http://dx.doi.org/10.1371/journal.pone.0144940

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