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Ultrasound-guided trans-rectal high-intensity focused ultrasound (HIFU) for advanced cervical cancer ablation is feasible: a case report

INTRODUCTION: High-intensity focused ultrasound (HIFU) is an ablative treatment undergoing assessment for the treatment of benign and malignant disease. We describe the first reported intracavitary HIFU ablation for recurrent, unresectable and symptomatic cervical cancer. CASE DESCRIPTION: A 38 year...

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Autores principales: Abel, M., Ahmed, H., Leen, E., Park, E., Chen, M., Wasan, H., Price, P., Monzon, L., Gedroyc, W., Abel, P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684617/
https://www.ncbi.nlm.nih.gov/pubmed/26688729
http://dx.doi.org/10.1186/s40349-015-0043-6
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author Abel, M.
Ahmed, H.
Leen, E.
Park, E.
Chen, M.
Wasan, H.
Price, P.
Monzon, L.
Gedroyc, W.
Abel, P.
author_facet Abel, M.
Ahmed, H.
Leen, E.
Park, E.
Chen, M.
Wasan, H.
Price, P.
Monzon, L.
Gedroyc, W.
Abel, P.
author_sort Abel, M.
collection PubMed
description INTRODUCTION: High-intensity focused ultrasound (HIFU) is an ablative treatment undergoing assessment for the treatment of benign and malignant disease. We describe the first reported intracavitary HIFU ablation for recurrent, unresectable and symptomatic cervical cancer. CASE DESCRIPTION: A 38 year old woman receiving palliative chemotherapy for metastatic cervical adenocarcinoma was offered ablative treatment from an intracavitary trans-rectal HIFU device (Sonablate® 500). Pre-treatment symptoms included vaginal bleeding and discharge that were sufficient to impede her quality of life. No peri-procedural adverse events occurred. Symptoms resolved completely immediately post-procedure, reappeared at 7 days, increasing to pre-procedural levels by day 30. DISCUSSION AND EVALUATION: This first time experience of intracavitary cervical HIFU suggests that it is feasible for palliation of advanced cervical cancer, with no early evidence of unexpected toxicity. Ethical approval had also been granted for the use of per-vaginal access if appropriate. This route, alone or in combination with the rectal route, may provide increased accessibility in future patients with a redesigned device more suited to trans-vaginal ablations. CONCLUSION: Intracavitary HIFU is a potentially safe procedure for the treatment of cervical cancer and able to provide symptomatic improvement in the palliative setting.
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spelling pubmed-46846172015-12-20 Ultrasound-guided trans-rectal high-intensity focused ultrasound (HIFU) for advanced cervical cancer ablation is feasible: a case report Abel, M. Ahmed, H. Leen, E. Park, E. Chen, M. Wasan, H. Price, P. Monzon, L. Gedroyc, W. Abel, P. J Ther Ultrasound Case Study INTRODUCTION: High-intensity focused ultrasound (HIFU) is an ablative treatment undergoing assessment for the treatment of benign and malignant disease. We describe the first reported intracavitary HIFU ablation for recurrent, unresectable and symptomatic cervical cancer. CASE DESCRIPTION: A 38 year old woman receiving palliative chemotherapy for metastatic cervical adenocarcinoma was offered ablative treatment from an intracavitary trans-rectal HIFU device (Sonablate® 500). Pre-treatment symptoms included vaginal bleeding and discharge that were sufficient to impede her quality of life. No peri-procedural adverse events occurred. Symptoms resolved completely immediately post-procedure, reappeared at 7 days, increasing to pre-procedural levels by day 30. DISCUSSION AND EVALUATION: This first time experience of intracavitary cervical HIFU suggests that it is feasible for palliation of advanced cervical cancer, with no early evidence of unexpected toxicity. Ethical approval had also been granted for the use of per-vaginal access if appropriate. This route, alone or in combination with the rectal route, may provide increased accessibility in future patients with a redesigned device more suited to trans-vaginal ablations. CONCLUSION: Intracavitary HIFU is a potentially safe procedure for the treatment of cervical cancer and able to provide symptomatic improvement in the palliative setting. BioMed Central 2015-12-18 /pmc/articles/PMC4684617/ /pubmed/26688729 http://dx.doi.org/10.1186/s40349-015-0043-6 Text en © Abel et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Study
Abel, M.
Ahmed, H.
Leen, E.
Park, E.
Chen, M.
Wasan, H.
Price, P.
Monzon, L.
Gedroyc, W.
Abel, P.
Ultrasound-guided trans-rectal high-intensity focused ultrasound (HIFU) for advanced cervical cancer ablation is feasible: a case report
title Ultrasound-guided trans-rectal high-intensity focused ultrasound (HIFU) for advanced cervical cancer ablation is feasible: a case report
title_full Ultrasound-guided trans-rectal high-intensity focused ultrasound (HIFU) for advanced cervical cancer ablation is feasible: a case report
title_fullStr Ultrasound-guided trans-rectal high-intensity focused ultrasound (HIFU) for advanced cervical cancer ablation is feasible: a case report
title_full_unstemmed Ultrasound-guided trans-rectal high-intensity focused ultrasound (HIFU) for advanced cervical cancer ablation is feasible: a case report
title_short Ultrasound-guided trans-rectal high-intensity focused ultrasound (HIFU) for advanced cervical cancer ablation is feasible: a case report
title_sort ultrasound-guided trans-rectal high-intensity focused ultrasound (hifu) for advanced cervical cancer ablation is feasible: a case report
topic Case Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684617/
https://www.ncbi.nlm.nih.gov/pubmed/26688729
http://dx.doi.org/10.1186/s40349-015-0043-6
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