A synthetic lethal approach for compound and target identification in Staphylococcus aureus

The majority of bacterial proteins are dispensable for growth in the laboratory, but nevertheless play important physiological roles. There are no systematic approaches to identify cell-permeable small molecule inhibitors of these proteins. We demonstrate a strategy to identify such inhibitors that...

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Detalles Bibliográficos
Autores principales: Pasquina, Lincoln, Maria, John P. Santa, Wood, B. McKay, Moussa, Samir H., Matano, Leigh, Santiago, Marina, Martin, Sara E. S., Lee, Wonsik, Meredith, Timothy C., Walker, Suzanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684722/
https://www.ncbi.nlm.nih.gov/pubmed/26619249
http://dx.doi.org/10.1038/nchembio.1967

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684722/
https://www.ncbi.nlm.nih.gov/pubmed/26619249
http://dx.doi.org/10.1038/nchembio.1967

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