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De novo design of a four-fold symmetric TIM-barrel protein with atomic-level accuracy
Despite efforts for over 25 years, de novo protein design has not succeeded in achieving the TIM-barrel fold. Here we describe the computational design of 4-fold symmetrical (β/α)(8)-barrels guided by geometrical and chemical principles. Experimental characterization of 33 designs revealed the impor...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684731/ https://www.ncbi.nlm.nih.gov/pubmed/26595462 http://dx.doi.org/10.1038/nchembio.1966 |