Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction

Aerobic glycolysis regulates T cell function. However, if and how primary cancer alters T cell glycolytic metabolism and affects tumor immunity remains a question in cancer patients. Here we report that ovarian cancers imposed glucose restriction on T cells and dampened their function via maintainin...

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Detalles Bibliográficos
Autores principales: Zhao, Ende, Maj, Tomasz, Kryczek, Ilona, Li, Wei, Wu, Ke, Zhao, Lili, Wei, Shuang, Crespo, Joel, Wan, Shanshan, Vatan, Linda, Szeliga, Wojciech, Shao, Irene, Wang, Yin, Liu, Yan, Varambally, Sooryanarayana, Chinnaiyan, Arul M., Welling, Theodore H., Marquez, Victor E., Kotarski, Jan, Wang, Hongbo, Wang, Zehua, Zhang, Yi, Liu, Rebecca, Wang, Guobin, Zou, Weiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684796/
https://www.ncbi.nlm.nih.gov/pubmed/26523864
http://dx.doi.org/10.1038/ni.3313

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