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Mitochondrial Dysfunction and Autophagy in Hepatic Ischemia/Reperfusion Injury
Ischemia/reperfusion (I/R) injury remains a major complication of liver resection, transplantation, and hemorrhagic shock. Although the mechanisms that contribute to hepatic I/R are complex and diverse involving the interaction of cell injury in hepatocytes, immune cells, and endothelium, mitochondr...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684839/ https://www.ncbi.nlm.nih.gov/pubmed/26770970 http://dx.doi.org/10.1155/2015/183469 |
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author | Go, Kristina L. Lee, Sooyeon Zendejas, Ivan Behrns, Kevin E. Kim, Jae-Sung |
author_facet | Go, Kristina L. Lee, Sooyeon Zendejas, Ivan Behrns, Kevin E. Kim, Jae-Sung |
author_sort | Go, Kristina L. |
collection | PubMed |
description | Ischemia/reperfusion (I/R) injury remains a major complication of liver resection, transplantation, and hemorrhagic shock. Although the mechanisms that contribute to hepatic I/R are complex and diverse involving the interaction of cell injury in hepatocytes, immune cells, and endothelium, mitochondrial dysfunction is a cardinal event culminating in hepatic reperfusion injury. Mitochondrial autophagy, so-called mitophagy, is a key cellular process that regulates mitochondrial homeostasis and eliminates damaged mitochondria in a timely manner. Growing evidence accumulates that I/R injury is attributed to defective mitophagy. This review aims to summarize the current understanding of autophagy and its role in hepatic I/R injury and highlight the various therapeutic approaches that have been studied to ameliorate injury. |
format | Online Article Text |
id | pubmed-4684839 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-46848392016-01-14 Mitochondrial Dysfunction and Autophagy in Hepatic Ischemia/Reperfusion Injury Go, Kristina L. Lee, Sooyeon Zendejas, Ivan Behrns, Kevin E. Kim, Jae-Sung Biomed Res Int Review Article Ischemia/reperfusion (I/R) injury remains a major complication of liver resection, transplantation, and hemorrhagic shock. Although the mechanisms that contribute to hepatic I/R are complex and diverse involving the interaction of cell injury in hepatocytes, immune cells, and endothelium, mitochondrial dysfunction is a cardinal event culminating in hepatic reperfusion injury. Mitochondrial autophagy, so-called mitophagy, is a key cellular process that regulates mitochondrial homeostasis and eliminates damaged mitochondria in a timely manner. Growing evidence accumulates that I/R injury is attributed to defective mitophagy. This review aims to summarize the current understanding of autophagy and its role in hepatic I/R injury and highlight the various therapeutic approaches that have been studied to ameliorate injury. Hindawi Publishing Corporation 2015 2015-12-06 /pmc/articles/PMC4684839/ /pubmed/26770970 http://dx.doi.org/10.1155/2015/183469 Text en Copyright © 2015 Kristina L. Go et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Go, Kristina L. Lee, Sooyeon Zendejas, Ivan Behrns, Kevin E. Kim, Jae-Sung Mitochondrial Dysfunction and Autophagy in Hepatic Ischemia/Reperfusion Injury |
title | Mitochondrial Dysfunction and Autophagy in Hepatic Ischemia/Reperfusion Injury |
title_full | Mitochondrial Dysfunction and Autophagy in Hepatic Ischemia/Reperfusion Injury |
title_fullStr | Mitochondrial Dysfunction and Autophagy in Hepatic Ischemia/Reperfusion Injury |
title_full_unstemmed | Mitochondrial Dysfunction and Autophagy in Hepatic Ischemia/Reperfusion Injury |
title_short | Mitochondrial Dysfunction and Autophagy in Hepatic Ischemia/Reperfusion Injury |
title_sort | mitochondrial dysfunction and autophagy in hepatic ischemia/reperfusion injury |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684839/ https://www.ncbi.nlm.nih.gov/pubmed/26770970 http://dx.doi.org/10.1155/2015/183469 |
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