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Bufalin Inhibits HCT116 Colon Cancer Cells and Its Orthotopic Xenograft Tumor in Mice Model through Genes Related to Apoptotic and PTEN/AKT Pathways

Aims. To investigate the anticolorectal cancer (CRC) effects of Bufalin, a bioactive polyhydroxysteroid from Venenum Bufonis, using HCT116 human CRC cell and an established orthotopic xenograft model in mice, and to explore the mechanisms of action. Material and Methods. Cultured HCT116 cells or BAL...

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Detalles Bibliográficos
Autores principales:	Wang, Jie, Chen, Chao, Wang, Shiying, Zhang, Yong, Yin, Peihao, Gao, Zhongxiang, Xu, Jie, Feng, Dianxu, Zuo, Qinsong, Zhao, Ronghua, Chen, Teng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685085/ https://www.ncbi.nlm.nih.gov/pubmed/26770191 http://dx.doi.org/10.1155/2015/457193

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