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The importance of binder moisture content in Metformin HCL high-dose formulations prepared by moist aqueous granulation (MAG)
The aim of this study was to evaluate binders to improve the flowability of granulates and compactibility of Metformin HCL (Met) using the moist aqueous granulation (MAG) process. The effect of the binder moisture content on granulate and tablet quality was also evaluated. Vinylpyrrolidone–vinyl ace...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685212/ https://www.ncbi.nlm.nih.gov/pubmed/26779418 http://dx.doi.org/10.1016/j.rinphs.2015.09.001 |