In quest of genomic treasure

It should be emphasized that “129” is not simply a number but is also the designation of a mouse strain that has made a great contribution to modern biological science and technology. Embryonic stem cells derived from 129 mice were essential components of gene-targeting strategies in early research....

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Detalles Bibliográficos
Autores principales: INOUE, Kimiko, OGURA, Atsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Society for Reproduction and Development 2015
Materias:
Opinions and Hypotheses
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685213/
https://www.ncbi.nlm.nih.gov/pubmed/26400375
http://dx.doi.org/10.1262/jrd.2015-098
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author INOUE, Kimiko
OGURA, Atsuo
author_facet INOUE, Kimiko
OGURA, Atsuo
author_sort INOUE, Kimiko
collection PubMed
description It should be emphasized that “129” is not simply a number but is also the designation of a mouse strain that has made a great contribution to modern biological science and technology. Embryonic stem cells derived from 129 mice were essential components of gene-targeting strategies in early research. More recently, 129 mice have provided superior donor genomes for cloning by nuclear transfer. Some factor or factors conferring genomic plasticity must exist in the 129 genome, but these remain unidentified.
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spelling pubmed-46852132015-12-22 In quest of genomic treasure INOUE, Kimiko OGURA, Atsuo J Reprod Dev Opinions and Hypotheses It should be emphasized that “129” is not simply a number but is also the designation of a mouse strain that has made a great contribution to modern biological science and technology. Embryonic stem cells derived from 129 mice were essential components of gene-targeting strategies in early research. More recently, 129 mice have provided superior donor genomes for cloning by nuclear transfer. Some factor or factors conferring genomic plasticity must exist in the 129 genome, but these remain unidentified. The Society for Reproduction and Development 2015-09-20 2015-12 /pmc/articles/PMC4685213/ /pubmed/26400375 http://dx.doi.org/10.1262/jrd.2015-098 Text en ©2015 Society for Reproduction and Development http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
spellingShingle Opinions and Hypotheses
INOUE, Kimiko
OGURA, Atsuo
In quest of genomic treasure
title In quest of genomic treasure
title_full In quest of genomic treasure
title_fullStr In quest of genomic treasure
title_full_unstemmed In quest of genomic treasure
title_short In quest of genomic treasure
title_sort in quest of genomic treasure
topic Opinions and Hypotheses
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685213/
https://www.ncbi.nlm.nih.gov/pubmed/26400375
http://dx.doi.org/10.1262/jrd.2015-098
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