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Nonvisible tumors on multiparametric magnetic resonance imaging does not predict low-risk prostate cancer

PURPOSE: To determine whether multiparametric MRI could help predict the diagnosis of low-risk prostate cancer (PCA). METHODS: We retrospectively analyzed consecutive 623 patients with PCA who underwent multiparametric MRI before radical prostatectomy(RP). High-resolution T1- and T2-weighted, diffus...

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Autores principales: Lee, Seung Hwan, Koo, Kyo Chul, Lee, Dong Hoon, Chung, Byung Ha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Asian Pacific Prostate Society 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685234/
https://www.ncbi.nlm.nih.gov/pubmed/26779459
http://dx.doi.org/10.1016/j.prnil.2015.09.005
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author Lee, Seung Hwan
Koo, Kyo Chul
Lee, Dong Hoon
Chung, Byung Ha
author_facet Lee, Seung Hwan
Koo, Kyo Chul
Lee, Dong Hoon
Chung, Byung Ha
author_sort Lee, Seung Hwan
collection PubMed
description PURPOSE: To determine whether multiparametric MRI could help predict the diagnosis of low-risk prostate cancer (PCA). METHODS: We retrospectively analyzed consecutive 623 patients with PCA who underwent multiparametric MRI before radical prostatectomy(RP). High-resolution T1- and T2-weighted, diffusion-weighted, and dynamic precontrast and postcontrast image sequences were obtained for each patient. Of the 623 patients, 177(28.4%) exhibited non visible tumors on MRI of clinical stage T1c. The imaging results were compared with the pathological findings with respect to both stage and Gleason scores (GS). RESULTS: Of the 177 prostatectomy patients with non visible tumors on MRI, pathological findings resulted in the upgrading of 49(27.7%) patients to a sum of GS 7 or more. 101(57.1%) patients exhibited tumor volumes greater than 0.5cc. The biochemical recurrence rate was significantly higher in the pathological upgraded group compared with the nonupgraded group after a mean follow-up time of 29 months. In the multiple logistic analysis, non visible tumor on MRI was not a significant predictor of low-risk PCA. CONCLUSIONS: Even though cancer foci were not visualized by postbiopsy MRI, the pathological tumor volumes and extent of GS upgrading were relatively high. Therefore, nonvisible tumors by multiparametric MRI do not appear to be predictive of low-risk PCA.
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spelling pubmed-46852342016-01-15 Nonvisible tumors on multiparametric magnetic resonance imaging does not predict low-risk prostate cancer Lee, Seung Hwan Koo, Kyo Chul Lee, Dong Hoon Chung, Byung Ha Prostate Int Original Article PURPOSE: To determine whether multiparametric MRI could help predict the diagnosis of low-risk prostate cancer (PCA). METHODS: We retrospectively analyzed consecutive 623 patients with PCA who underwent multiparametric MRI before radical prostatectomy(RP). High-resolution T1- and T2-weighted, diffusion-weighted, and dynamic precontrast and postcontrast image sequences were obtained for each patient. Of the 623 patients, 177(28.4%) exhibited non visible tumors on MRI of clinical stage T1c. The imaging results were compared with the pathological findings with respect to both stage and Gleason scores (GS). RESULTS: Of the 177 prostatectomy patients with non visible tumors on MRI, pathological findings resulted in the upgrading of 49(27.7%) patients to a sum of GS 7 or more. 101(57.1%) patients exhibited tumor volumes greater than 0.5cc. The biochemical recurrence rate was significantly higher in the pathological upgraded group compared with the nonupgraded group after a mean follow-up time of 29 months. In the multiple logistic analysis, non visible tumor on MRI was not a significant predictor of low-risk PCA. CONCLUSIONS: Even though cancer foci were not visualized by postbiopsy MRI, the pathological tumor volumes and extent of GS upgrading were relatively high. Therefore, nonvisible tumors by multiparametric MRI do not appear to be predictive of low-risk PCA. Asian Pacific Prostate Society 2015-12 2015-10-08 /pmc/articles/PMC4685234/ /pubmed/26779459 http://dx.doi.org/10.1016/j.prnil.2015.09.005 Text en Copyright © 2015 Asian Pacific Prostate Society, Published by Elsevier. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Lee, Seung Hwan
Koo, Kyo Chul
Lee, Dong Hoon
Chung, Byung Ha
Nonvisible tumors on multiparametric magnetic resonance imaging does not predict low-risk prostate cancer
title Nonvisible tumors on multiparametric magnetic resonance imaging does not predict low-risk prostate cancer
title_full Nonvisible tumors on multiparametric magnetic resonance imaging does not predict low-risk prostate cancer
title_fullStr Nonvisible tumors on multiparametric magnetic resonance imaging does not predict low-risk prostate cancer
title_full_unstemmed Nonvisible tumors on multiparametric magnetic resonance imaging does not predict low-risk prostate cancer
title_short Nonvisible tumors on multiparametric magnetic resonance imaging does not predict low-risk prostate cancer
title_sort nonvisible tumors on multiparametric magnetic resonance imaging does not predict low-risk prostate cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685234/
https://www.ncbi.nlm.nih.gov/pubmed/26779459
http://dx.doi.org/10.1016/j.prnil.2015.09.005
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