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Nonvisible tumors on multiparametric magnetic resonance imaging does not predict low-risk prostate cancer
PURPOSE: To determine whether multiparametric MRI could help predict the diagnosis of low-risk prostate cancer (PCA). METHODS: We retrospectively analyzed consecutive 623 patients with PCA who underwent multiparametric MRI before radical prostatectomy(RP). High-resolution T1- and T2-weighted, diffus...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Asian Pacific Prostate Society
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685234/ https://www.ncbi.nlm.nih.gov/pubmed/26779459 http://dx.doi.org/10.1016/j.prnil.2015.09.005 |
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author | Lee, Seung Hwan Koo, Kyo Chul Lee, Dong Hoon Chung, Byung Ha |
author_facet | Lee, Seung Hwan Koo, Kyo Chul Lee, Dong Hoon Chung, Byung Ha |
author_sort | Lee, Seung Hwan |
collection | PubMed |
description | PURPOSE: To determine whether multiparametric MRI could help predict the diagnosis of low-risk prostate cancer (PCA). METHODS: We retrospectively analyzed consecutive 623 patients with PCA who underwent multiparametric MRI before radical prostatectomy(RP). High-resolution T1- and T2-weighted, diffusion-weighted, and dynamic precontrast and postcontrast image sequences were obtained for each patient. Of the 623 patients, 177(28.4%) exhibited non visible tumors on MRI of clinical stage T1c. The imaging results were compared with the pathological findings with respect to both stage and Gleason scores (GS). RESULTS: Of the 177 prostatectomy patients with non visible tumors on MRI, pathological findings resulted in the upgrading of 49(27.7%) patients to a sum of GS 7 or more. 101(57.1%) patients exhibited tumor volumes greater than 0.5cc. The biochemical recurrence rate was significantly higher in the pathological upgraded group compared with the nonupgraded group after a mean follow-up time of 29 months. In the multiple logistic analysis, non visible tumor on MRI was not a significant predictor of low-risk PCA. CONCLUSIONS: Even though cancer foci were not visualized by postbiopsy MRI, the pathological tumor volumes and extent of GS upgrading were relatively high. Therefore, nonvisible tumors by multiparametric MRI do not appear to be predictive of low-risk PCA. |
format | Online Article Text |
id | pubmed-4685234 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Asian Pacific Prostate Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-46852342016-01-15 Nonvisible tumors on multiparametric magnetic resonance imaging does not predict low-risk prostate cancer Lee, Seung Hwan Koo, Kyo Chul Lee, Dong Hoon Chung, Byung Ha Prostate Int Original Article PURPOSE: To determine whether multiparametric MRI could help predict the diagnosis of low-risk prostate cancer (PCA). METHODS: We retrospectively analyzed consecutive 623 patients with PCA who underwent multiparametric MRI before radical prostatectomy(RP). High-resolution T1- and T2-weighted, diffusion-weighted, and dynamic precontrast and postcontrast image sequences were obtained for each patient. Of the 623 patients, 177(28.4%) exhibited non visible tumors on MRI of clinical stage T1c. The imaging results were compared with the pathological findings with respect to both stage and Gleason scores (GS). RESULTS: Of the 177 prostatectomy patients with non visible tumors on MRI, pathological findings resulted in the upgrading of 49(27.7%) patients to a sum of GS 7 or more. 101(57.1%) patients exhibited tumor volumes greater than 0.5cc. The biochemical recurrence rate was significantly higher in the pathological upgraded group compared with the nonupgraded group after a mean follow-up time of 29 months. In the multiple logistic analysis, non visible tumor on MRI was not a significant predictor of low-risk PCA. CONCLUSIONS: Even though cancer foci were not visualized by postbiopsy MRI, the pathological tumor volumes and extent of GS upgrading were relatively high. Therefore, nonvisible tumors by multiparametric MRI do not appear to be predictive of low-risk PCA. Asian Pacific Prostate Society 2015-12 2015-10-08 /pmc/articles/PMC4685234/ /pubmed/26779459 http://dx.doi.org/10.1016/j.prnil.2015.09.005 Text en Copyright © 2015 Asian Pacific Prostate Society, Published by Elsevier. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Lee, Seung Hwan Koo, Kyo Chul Lee, Dong Hoon Chung, Byung Ha Nonvisible tumors on multiparametric magnetic resonance imaging does not predict low-risk prostate cancer |
title | Nonvisible tumors on multiparametric magnetic resonance imaging does not predict low-risk prostate cancer |
title_full | Nonvisible tumors on multiparametric magnetic resonance imaging does not predict low-risk prostate cancer |
title_fullStr | Nonvisible tumors on multiparametric magnetic resonance imaging does not predict low-risk prostate cancer |
title_full_unstemmed | Nonvisible tumors on multiparametric magnetic resonance imaging does not predict low-risk prostate cancer |
title_short | Nonvisible tumors on multiparametric magnetic resonance imaging does not predict low-risk prostate cancer |
title_sort | nonvisible tumors on multiparametric magnetic resonance imaging does not predict low-risk prostate cancer |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685234/ https://www.ncbi.nlm.nih.gov/pubmed/26779459 http://dx.doi.org/10.1016/j.prnil.2015.09.005 |
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